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12. Morphological characteristics of lungs in the dynamics of development of a new experimental model of surgical sepsis
- Creator:
- Azizov, Yorkin and Ohunov, Alisher
- Format:
- braille, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, statistics, and TEXT
- Subject:
- plíce--anatomie a histologie--patofyziologie, sepse--patologie, stupeň závažnosti nemoci, výzkumný projekt, nekróza--etiologie, syndrom respirační tísně dospělých--etiologie--patofyziologie, modely nemocí na zvířatech, králíci, plicní oběh--fyziologie, infekce měkkých tkání--patofyziologie, časové faktory, and zvířata
- Language:
- English
- Description:
- This is an experimental study of lung morphology in modeling sepsis on a background of severe purulentinflammatory disease of soft tissues (necrotizing fasciitis) by original authors' method. The study showed that early stages of sepsis (13 days) were characterized by manifestations of changes in lung tissue as vascular response, in the second period (the 7th day) by appearance and growth of nonobstructive microatelectases, whereas the third period (the 14th day) was characterized by progression of purulentnecrotic processes in soft tissues, development of surgical sepsis and acute respiratory distress syndrome. These changes in morphological structure of lung tissue are specific for generalized septic process and consequences of necrotizing fasciitis with its septic complication., Yorkin Azizov, Alisher Ohunov, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
13. Nerve stretch injury induced pain pattern and changes in sensory ganglia in a clinically relevant model of limb-lengthening in rabbits
- Creator:
- Pap, K., Berta, Á., Szöke, G., Dunay, M., Németh, T., Hornok, K., Marosföi, L., Réthelyi, M., Kozsurek, M., and Puskár, Z.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, neuropatická bolest, králíci, neuropathic pain, rabbits, limb-lengthening, substance P, DRG, postoperative pain, 14, and 612
- Language:
- English
- Description:
- We used a model of tibial lengthening in rabbits to study the postoperative pain pattern during limb-lengthening and morphological changes in the dorsal root ganglia (DRG), including alteration of substance P (SP) expression. Four groups of animals (naïve; OG: osteotomized only group; SDG/FDG: slow/fast distraction groups, with 1 mm/3 mm lengthening a day, respectively) were used. Signs of increasing postoperative pain were detected until the 10th postoperative day in OG/SDG/FDG, then they decreased in OG but remained higher in SDG/FDG until the distraction finished, suggesting that the pain response is based mainly on surgical trauma until the 10th day, while the lengthening extended its duration and increased its intensity. The only morphological change observed in the DRGs was the presence of large vacuoles in some large neurons of OG/SDG/FDG. Cell size analysis of the S1 DRGs showed no cell loss in any of the three groups; a significant increase in the number of SP-positive large DRG cells in the OG; and a significant decrease in the number of SP-immunoreactive small DRG neurons in the SDG/FDG. Faster and larger distraction resulted in more severe signs of pain sensation, and further reduced the number of SP-positive small cells, compared to slow distraction., K. Pap, Á. Berta, G. Szöke, M. Dunay, T. Németh, K. Hornok, L. Marosföi, M. Réthelyi, M. Kozsurek, Z. Puskár., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
14. Radiofrequency electromagnetic field affects heart rate variability in rabbits
- Creator:
- Míšek, Jakub, Veterník, Marcel, Tonhajzerová, Ingrid, Jakušová, Viera, Janousek, Ladislav, and Jakuš, Ján
- Format:
- počítač and online zdroj
- Type:
- model:article and TEXT
- Subject:
- mobilní komunikace, králíci, fyziologie, mobile communication, rabbits, physiology, cardiac autonomic regulation, cell phone, radiofrequency electromagnetic exposure, 14, and 612
- Language:
- English
- Description:
- The aim of this study was to assess the effects of radiofrequency electromagnetic field (RF EMF) on heart rate variability (HRV) in rabbits with intensity slightly exceeding the limits for occupations. Totally 21 New Zealand white rabbits divided into two groups were used in this double-blind study. The first group of animals without general anesthesia was subjected to HRV examination under exposure to a device generated RF EMF source (frequency 1788 MHz, intensity 160 V/m, lasting 150 min.). The second group (premedications + α chloralose mg/kg) underwent the same protocol under the exposure to the real RF EMF signal from the base stations of mobile providers (frequency range 1805 - 1870 MHz - corresponding to the downlink signal of Slovak mobile providers, 160 V/m, 150 min., respectively). Individual 5-min records were used to analyze the HRV parameters: heart rate and root Mean Square of the Successive Differences (rMSSD) for time domain analysis and spectral powers in the low (LF-VFS) and high frequency (HF-VFS) bands for frequency domain analysis. Our study revealed the increased in HRV parameters (HF-HRV, rMSSD) associated with lower heart rate indicating increased cardiac vagal control under the exposure to RF EMF in experimental methods., Jakub Misek, Marcel Veterník, Ingrid Tonhajzerova, Viera Jakusova, Ladislav Janousek, Jan Jakus., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
15. Short-term changes of NADPH diaphorase-exhibiting neuronal pools in the spinal cord of rabbit after repeated sublethal ischemia
- Creator:
- Jozef Maršala and Jalč, P.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, mícha, králíci, spinal cord, rabbits, NADPH diaphorase, sublethal ischemia, 14, and 612
- Language:
- English
- Description:
- The aim of this study was the histochemical characterization of NADPH diaphorase-positive neuronal pools in the rabbit lumbosacral segments using a model of single, repeated and multiple sublethal spinal cord ischemia. Following a single 8-min sublethal spinal cord ischemia and 1-hour reperfusion, the staining of NADPH diaphorase-exhibiting neurons in the dorsal horn, pericentral region, dorsal gray commissure and sacral parasympathetic nucleus was comparable with the control sections. In contrast to the foregoing sublethal ischemia, a regionally different somatic NADPH diaphorase (NADPHd) staining was found after multiple sublethal spinal cord ischemia. Whereas an almost complete loss of the staining of large NADPHd-exhibiting somata in the pericentral region was detected, the staining of the NADPHd-exhibiting neuronal pools in the deep dorsal horn and sacral parasympathetic nucleus was fully preserved. Concomitantly, a prominent reduction of small NADPH diaphorase -positive neurons was noted in the superficial dorsal horn layers of lower lumbar and sacral segments., J. Maršala, P. Jalč., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
16. The effect of HT-2 toxin on ovarian steroidogenesis and its response to IGF-I, leptin and ghrelin in rabbits
- Creator:
- Kolesarova, A., Maruniakova, N., Kadasi, A., Halenar, M., Marak, M., and Alexander V. Sirotkin
- Format:
- print, bez média, and svazek
- Type:
- article, články, journal articles, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, leptin, vaječníky, králíci, ovaries, rabbits, trichothecenes, IGF-I, ghrelin, steroidogenesis, 14, and 612
- Language:
- English
- Description:
- T-2 toxin and its metabolite HT-2 toxin are one of the most toxic mycotoxins of type A-trichothecenes, which are produced mainly by Fusarium species. Therefore, study of Fusarium toxins T-2 toxin and HT-2 toxin is an essential issue because they could also play role in failures of reproductive functions as well as endocrine system of domestic animals. Assessment of the effect of A-trichothecene mycotoxin HT-2 toxin alone or combined with insulin-like growth factor (IGF-I), leptin and ghrelin on estradiol secretion by rabbit ovarian fragments in vitro was done. Rabbit ovarian fragments were incubated without (control group) or with HT-2 toxin, or its combinations with IGF-I, leptin and ghrelin at various concentrations for 24 h. Secretion of 17β-estradiol was determined by ELISA. Firstly, HT-2 toxin at the doses 10 and 100 ng.ml-1, but not at 1 ng.ml-1 decreased 17β-estradiol secretion by ovarian fragments. Secondly, 17β-estradiol secretion was not affected by HT-2 toxin exposure combined with growth factor IGF-I, metabolic hormones leptin and ghrelin. In conclusion, HT-2 toxin has potent direct dose-dependent effects on ovarian steroidogenesis in rabbits. These direct effects of HT-2 mycotoxin on ovarian steroidogenesis could impact negatively on the reproductive performance of rabbits., A. Kolesarova, N. Maruniakova, A. Kadasi, M. Halenar, M. Marak, A. V. Sirotkin., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
17. The effect of hyperthermia in vitro on vitality of rabbit preimplantation embryos
- Creator:
- Alexander Makarevič, Olexiikova, L., Peter Chrenek, Elena Kubovičová, Fréharová, K., and Juraj Pivko
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Obecná zoologie, fyziologie živočichů, králíci, embryogeneze živočichů, hypertermie, apoptóza, animal physiology, rabbits, animal embryology, hyperthermia, apoptosis, Hsp70, actin, 2, and 591
- Language:
- English
- Description:
- The aim of our study was to test the in fluence of short exposure (6 h) of preimplantation rabbit embryos to elevated temperatures (41.5 ºC or 42.5 ºC) in vitro on their developmental capacity. Fertilized eggs recovered from female oviducts at the pronuclear stage (19 hpc) were cultured at standard temperature (37.5 ºC) until the morula stage (72 hpc). Afterwards, the embryos were divided into two groups, cultured for 6 h either at hyperthermic (41.5 ºC or 42.5 ºC) or standard temperature (control 37.5 ºC), post-incubated overnight (16-20 h) at 37.5 ºC and then evaluated for developmental stages, apoptosis (TUNEL), proliferation (cell number), actin cytoskeleton and presence of heat-shock proteins Hsp70. It was observed that hyperthermia at 41.5 ºC did not alter progression of embryos to higher preimplantation stages (expanded and hatching/hatched blastocysts), rate of apoptosis, total cell number of blastocysts and structure of actin filament compared to 37.5 ºC. We stern-blotting revealed the presence of heat stress-induced 72 kDa fraction of Hsp70 proteins in granulosa cells (exposed to 41 ºC) and embryos (exposed to 41.5 ºC). Following the elevation of temperature to 42.5 ºC embryo development was dramati cally compromised. The embryos were arrested at the morula or early blastocyst stage, showed an increased rate of apoptosis and decreased total cell number compared to control. The structure of actin filaments in most of blastomeres was damaged and such blastomeres often contained apoptotic nuclei. In this group a presence of heat-stress-induced fraction of Hsp70 proteins had not been confirmed. This is the first report demonstrating a threshold of thermotolerance of rabbit preimplantation embryos to hyperthermic exposure in vitro. A detrimental effect of higher temperature on the embryo is probably associated with the loss of their ability to produce Hsp70 de novo, which leads to cytoskeleton alterations and enhanced apoptosis., A. V. Makarevich, L. Olexiková, P. Chrenek, E. Kubovičová, K. Fréharová, J. Pivko., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
18. The electrocardiographic holter monitoring in experimental veterinary practice
- Creator:
- Peter Scheer, Petr Svoboda, Milan Sepši, Katarína Janečková, and Jaroslav Doubek
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, elektrokardiografie, králíci, kočky, psi, ovce, electrocardiography, rabbits, cats, dogs, sheep, ECG holter recording, rat, ferret, minipig, 14, and 612
- Language:
- English
- Description:
- The long-term electrocardiographic recording with retrospective evaluation (Holter system) has been widely used not only in cardiology, but also in other disciplines of internal medicine and in pharmaceutical research. The Holter system can be used in mini-pig, sheep, dog, cat, rabbit, ferret, and rat. In this paper hardware, software, and anesthesia requirements are summarized with respect to the experimental work with various species. As the Holter systems work in bipolar mode, the use of bipolar leads in sagittal and transversal planes has been proved to be the most appropriate because of large amplitude of QRS complex and uncomplicated consequent automatic analysis of the record. In conclusion, Holter electrocardiography represents a simple and applicable method for monitoring the electrical activity of the heart in small animals’ experimental studies., P. Scheer ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
19. Úprava zajíce v kuchyni: návod pro hospodyně i kuchařky, jak levně a úspěšně mohou upravovati různé pokrmy z masa zaječího : 58 předpisů, jež dle nejlepších spisů kuchařských, jakož i z vlastních zkušeností upravila Božena Jedličková : dodatkem připojeno 20 vyzkoušených předpisů, jak králičí maso nejvhodněji za pokrm upraviti možno
- Creator:
- Jedličková, Božena
- Publisher:
- knihkupectví A. Reinwart and "Politika"
- Format:
- svazek, bez média, print, text, regular print, and 45 stran ; 18 cm
- Type:
- model:monograph and TEXT
- Subject:
- 641/642, 639.112, 636.92, 637.55'712, 637.5'692, 637.55, (083.12), 641, 19, kuchařství, zajíci, králíci, zaječí maso, králičí maso, zvěřina, and Kuchařství. Potraviny. Vařená jídla
- Language:
- Czech
- Description:
- "... Připojené pojednání, které sestavila jsem dle nejlepších knih kuchařských a doplnila svými vlastními zkušenostmi, má za účel obeznámiti naše hospodyňky a kuchařky, jak si při úpravě této zvěřiny počínati mají, aby na stůl předložiti mohly nejen jídla chutná a výživná, ale i levně a úsporně využitkovati mohly všech součástí masa zaječího i králičího ..."--Úvod, Přívazek k: Rukověť lovectví : příručka pro myslivce, lovce a střelce / napsal Josef Schmoranz, Úprava masa králičího, and Converted from MODS 3.5 to DC version 1.8 (EE patch 2015/06/25)
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public