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Start Over Creator Milan Hájek

1. Composite hyaluronate-type I collagen-fibrin scaffold in the therapy of osteochondral defects in miniature pigs

Creator:
Elena Filová, Michala Rampichová, Milan Handl, Lytvynets, A., Roman Halouzka, Dušan Usvald, Jana Juhásová, Radek Procházka, Monika Dezortová, Eva Košťáková, Tomáš Trč, Eduard Šťastný, Koláčná, L., Milan Hájek, Jan Motlík, and Evžen Amler
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, osteochondral defect, fibrin, autologous chondrocytes, cartilage regeneration, 14, and 612
Language:
English
Description:
E. Filová, M. Rampichová, M. Handl, A. Lytvynets, R. Halouzka, D. Usvald, J. Hlučilová, R. Procházka, M. Dezortová, E. Rolencová, E. Košťáková, T. Trč, E. Šťastný, L. Koláčná, M. Hájek, J. Motlík, E. Amler. and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. Differences in muscle metabolism in patients with type I diabetes - influence of gender and nephropathy studied by 31P MR spectroscopy

Creator:
Sedivy, P., Monika Dezortová, Michal Drobný, Zuzana Vlasáková, Vít Herynek, and Milan Hájek
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
magnetická rezonanční spektroskopie, diabetes mellitus, energetický metabolismus, magnetic resonance spectroscopy, energy metabolism, Diabetes Mellitus Type I, 14, and 612
Language:
English
Description:
Type I diabetes mellitus (DM1) is a complex disease with adverse effects on organs and tissues despite compensation by insulin treatment. The goal of our study was to study how kidney diseases change 31P MR parameters of muscle metabolism in DM1 patients with respect to gender. 51 DM1 patients (19 m/14 f without and 13 m/5 f with nephropathy) and 26 (14 m/12 f) healthy volunteers were examined using 31P magnetic resonance spectroscopy at 3T tomograph at rest, and during and after a calf muscle exercise. The exercise consisted of a six-minute plantar flexion using a pedal ergometer followed by a six-minute recovery. It is reflected by reduced relative β-ATP and increased Pi and phosphodiester signals to phosphocreatine (PCr) at rest and prolongation of the PCr recovery time after the exercise. Measurement on healthy volunteers indicated differences between males and females in pH at the rest and after the exercise only. These differences between patients groups were not significant. We have proven that nephropathy affects the metabolism in diabetic patients and our results confirm significant difference between patients with and without nephropathy. Gender differences in pH were observed only between male and female healthy volunteers., P. Sedivy, M. Dezortova, M. Drobny, Z. Vlasakova, V. Herynek, M. Hajek., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3. Effect of acute hyperinsulinemia on brain metabolism evaluated by 1H MR spectroscopy - a pilot study

Creator:
Simona Kratochvílová, Antonín Škoch, Monika Dezortová, Švehlíková, E., Hill, M., Jana Brunová, Milan Hájek, and Terezie Pelikánová
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, hyperinzulinémie, magnetická rezonanční spektroskopie, diabetes mellitus, hyperinsulinism, magnetic resonance spectroscopy, brain glucose metabolism, hyperinsulinemic clamp, type 1 diabetes, 14, and 612
Language:
English
Description:
To determine whether acutely-induced supraphysiological hyperinsulinemia influences brain metabolism in patients with type 1 diabetes (D) and healthy controls (C) as detected by MR Spectroscopy. Group D consisted of 4 patients with the average duration of diabetes for 7 years. They were matched according to age, sex and BMI to 4 healthy controls. 1H MR Spectroscopy was performed with a 1.5 Tesla. Spectra were obtained from parietooccipital white matter repeatedly during a 3-h hyperinsulinemic euglycemic clamp with 2 mU.kg-1.min-1. In group D, significantly lower basal concentrations of N-acetylaspartate (p=0.02), choline (p=0.03), creatine (p=0.002) and inositol (p=0.007) were detected compared to C. After the induction of hyperinsulinemia, concentrations of choline, creatine, GABA, inositol, lactate, NAA and composite signal glutamate + glutamine (Glx) stayed stable. The detection of glucose signal is less realiable at 1.5 Tesla but we registered the alteration in glucose concentration (p=0.003) in the whole group. Originally sightly elevated glucose concentration in D decreased on the contrary to the increase of originally lower glucose level in C. In conclusions, brain metabolism was altered in D. Short term supraphysiological euglycemic hyperinsulinemia induced changes in the concentration of brain glucose in both C and D., S. Kratochvílová, A. Škoch, M. Dezortová, E. Švehlíková, M. Hill, J. Brunová, M. Hájek, T. Pelikánová., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

4. Influence of breathing on the measurement of lipids in the myocardium by 1H MR spectroscopy

Creator:
Drobný, M., Sedivy, P., Monika Dezortová, Wagnerova, D., and Milan Hájek
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, myokard, myocardium, lipid content, artifacts, 3T, 1H MR spectroscopy, 14, and 612
Language:
English
Description:
The myocardium examination by MR spectroscopy is very challenging due to movements caused by the cardiac rhythm and breathing. The aim of the study was to investigate the influence of breathing on the quantitative measurement of lipid/water ratios in different groups of volunteers and different measuring protocols. We examined the lipid content of myocardium at 3T using the proton single voxel spectroscopy. Three protocols (free breathing, breath hold and the use of respiratory navigator) controlled by ECG were used for t he examination of 42 adult volunteers including 14 free divers. Spectra were evaluated using jMRUI software. An average content of lipids in the healthy interventricular septum, gained by all protocols was equal to 0.6 %, which is in agreement with other p ublished data. Based on the quality of examinations and the highest technical success, the best protocol seems to be the one containing a respiratory navigator since it is more acceptable by patients. Based on our results and the literature data we can con clude that MR spectroscopy is able to distinguish patients from controls only if their myocardial lipid content is higher than 1.6 % (mean value of lipids plus two standard deviations)., M. Drobny, P. Sedeivy, M. Dezortova, D. Wagnerova, M. Hajek., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

5. Mikrovlnná recyklace PET lahví

Creator:
Milan Hájek
Type:
article, články, model:article, and TEXT
Subject:
Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, Ústav chemických procesů (Akademie věd ČR), věda, polyethylentereftalát, mikrovlnná chemie, science, mikrovlnná recyklace, 12, and 00
Language:
Czech
Description:
S rostoucí produkcí PET (polyethylentereftalát) obalů narůstají problémy s hromadícími se použitými obaly, a to především PET lahvemi. Většina netříděných odpadních PET obalů se však v současnosti likviduje spalováním. V Ústavu chemických procesů AV ČR jsme za účelem řešení tohoto problému vyvinuli unikátní technologii zpracování odpadního PET materiálu na produkty, které jsou použitelné k opětovné výrobě tohoto polymeru. Aktuálně se otevírá možnost jejího uplatnění v praxi. and Milan Hájek.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

6. The relationships between quantitative MR parameters in hippocampus in healthy subjects and patients with temporal lobe epilepsy

Creator:
Wagnerová, D., Vít Herynek, Monika Dezortová, Petr Marusič, Pavel Kršek, Josef Zámečník, Filip Jírů, Antonín Škoch, and Milan Hájek
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, temporální epilepsie, spektroskopie, temporal epilepsy, spectroscopy, temporal lobe epilepsy, 1H-MR spectroscopy, MR diffusometry, T2 relaxometry, correlations, 14, and 612
Language:
English
Description:
We introduce a new magnetic resonance (MR) method based on a pixel-by-pixel image processing to examine relationships between metabolic and structural processes in the pathologic hippocampus. The method was tested for lateralization of the epileptogenic zone in patients with temporal lobe epilepsy (TLE). Twenty patients with drug-resistant TLE and fifteen healthy controls were examined at 3T. The measurement protocol contained T2-weighted MR images, spectroscopic imaging, diffusion tensor imaging and T2 relaxometry. Correlations between quantitative MR parameters were calculated on a pixelby- pixel basis using the CORIMA program which enables automated pixel identification in the normal tissue according to control data. All MR parameters changed in the anteroposterior direction in the hippocampus and correlation patterns and their slopes differed between patients and controls. Combinations of T2 relaxation times with metabolite values represent the best biomarkers of the epileptogenic zone. Correlations with mean diffusivity did not provide sufficiently accurate results due to diffusion image distortions. Quantitative MR analysis noninvasively provides a detailed description of hippocampal pathology and may represent complementary tool to the standard clinical protocol. However, the automated processing should be carefully monitored in order to avoid possible errors caused by MR artifacts., D. Wagnerová, V. herynek, M. Dezortová, P. Marusič, P. Kršek, J. Zámečník, F. Jírů, A. Škoch, M. Hájek., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public