Differences in muscle metabolism in patients with type I diabetes - influence of gender and nephropathy studied by 31P MR spectroscopy

Title:

Differences in muscle metabolism in patients with type I diabetes - influence of gender and nephropathy studied by 31P MR spectroscopy

Creator:

Sedivy, P., Monika Dezortová, Michal Drobný, Zuzana Vlasáková, Vít Herynek, and Milan Hájek

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:62798ab2-729d-4c72-8548-ef46d5c1c53e
uuid:62798ab2-729d-4c72-8548-ef46d5c1c53e
issn:0862-8408

Subject:

magnetická rezonanční spektroskopie, diabetes mellitus, energetický metabolismus, magnetic resonance spectroscopy, energy metabolism, Diabetes Mellitus Type I, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Type I diabetes mellitus (DM1) is a complex disease with adverse effects on organs and tissues despite compensation by insulin treatment. The goal of our study was to study how kidney diseases change 31P MR parameters of muscle metabolism in DM1 patients with respect to gender. 51 DM1 patients (19 m/14 f without and 13 m/5 f with nephropathy) and 26 (14 m/12 f) healthy volunteers were examined using 31P magnetic resonance spectroscopy at 3T tomograph at rest, and during and after a calf muscle exercise. The exercise consisted of a six-minute plantar flexion using a pedal ergometer followed by a six-minute recovery. It is reflected by reduced relative β-ATP and increased Pi and phosphodiester signals to phosphocreatine (PCr) at rest and prolongation of the PCr recovery time after the exercise. Measurement on healthy volunteers indicated differences between males and females in pH at the rest and after the exercise only. These differences between patients groups were not significant. We have proven that nephropathy affects the metabolism in diabetic patients and our results confirm significant difference between patients with and without nephropathy. Gender differences in pH were observed only between male and female healthy volunteers., P. Sedivy, M. Dezortova, M. Drobny, Z. Vlasakova, V. Herynek, M. Hajek., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:3

Harvested from:

CDK

Metadata only:

false