The relationships between quantitative MR parameters in hippocampus in healthy subjects and patients with temporal lobe epilepsy

Title:

The relationships between quantitative MR parameters in hippocampus in healthy subjects and patients with temporal lobe epilepsy

Creator:

Wagnerová, D., Vít Herynek, Monika Dezortová, Petr Marusič, Pavel Kršek, Josef Zámečník, Filip Jírů, Antonín Škoch, and Milan Hájek

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1e34d5da-b817-44aa-9b50-f4430ad17f57
uuid:1e34d5da-b817-44aa-9b50-f4430ad17f57
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, temporální epilepsie, spektroskopie, temporal epilepsy, spectroscopy, temporal lobe epilepsy, 1H-MR spectroscopy, MR diffusometry, T2 relaxometry, correlations, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

We introduce a new magnetic resonance (MR) method based on a pixel-by-pixel image processing to examine relationships between metabolic and structural processes in the pathologic hippocampus. The method was tested for lateralization of the epileptogenic zone in patients with temporal lobe epilepsy (TLE). Twenty patients with drug-resistant TLE and fifteen healthy controls were examined at 3T. The measurement protocol contained T2-weighted MR images, spectroscopic imaging, diffusion tensor imaging and T2 relaxometry. Correlations between quantitative MR parameters were calculated on a pixelby- pixel basis using the CORIMA program which enables automated pixel identification in the normal tissue according to control data. All MR parameters changed in the anteroposterior direction in the hippocampus and correlation patterns and their slopes differed between patients and controls. Combinations of T2 relaxation times with metabolite values represent the best biomarkers of the epileptogenic zone. Correlations with mean diffusivity did not provide sufficiently accurate results due to diffusion image distortions. Quantitative MR analysis noninvasively provides a detailed description of hippocampal pathology and may represent complementary tool to the standard clinical protocol. However, the automated processing should be carefully monitored in order to avoid possible errors caused by MR artifacts., D. Wagnerová, V. herynek, M. Dezortová, P. Marusič, P. Kršek, J. Zámečník, F. Jírů, A. Škoch, M. Hájek., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:3

Harvested from:

CDK

Metadata only:

false