Effect of acute hyperinsulinemia on brain metabolism evaluated by 1H MR spectroscopy - a pilot study

Title:

Effect of acute hyperinsulinemia on brain metabolism evaluated by 1H MR spectroscopy - a pilot study

Creator:

Simona Kratochvílová, Antonín Škoch, Monika Dezortová, Švehlíková, E., Hill, M., Jana Brunová, Milan Hájek, and Terezie Pelikánová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6be92f4d-62c7-4790-9238-2b6d5cff2ecd
uuid:6be92f4d-62c7-4790-9238-2b6d5cff2ecd
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, hyperinzulinémie, magnetická rezonanční spektroskopie, diabetes mellitus, hyperinsulinism, magnetic resonance spectroscopy, brain glucose metabolism, hyperinsulinemic clamp, type 1 diabetes, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

To determine whether acutely-induced supraphysiological hyperinsulinemia influences brain metabolism in patients with type 1 diabetes (D) and healthy controls (C) as detected by MR Spectroscopy. Group D consisted of 4 patients with the average duration of diabetes for 7 years. They were matched according to age, sex and BMI to 4 healthy controls. 1H MR Spectroscopy was performed with a 1.5 Tesla. Spectra were obtained from parietooccipital white matter repeatedly during a 3-h hyperinsulinemic euglycemic clamp with 2 mU.kg-1.min-1. In group D, significantly lower basal concentrations of N-acetylaspartate (p=0.02), choline (p=0.03), creatine (p=0.002) and inositol (p=0.007) were detected compared to C. After the induction of hyperinsulinemia, concentrations of choline, creatine, GABA, inositol, lactate, NAA and composite signal glutamate + glutamine (Glx) stayed stable. The detection of glucose signal is less realiable at 1.5 Tesla but we registered the alteration in glucose concentration (p=0.003) in the whole group. Originally sightly elevated glucose concentration in D decreased on the contrary to the increase of originally lower glucose level in C. In conclusions, brain metabolism was altered in D. Short term supraphysiological euglycemic hyperinsulinemia induced changes in the concentration of brain glucose in both C and D., S. Kratochvílová, A. Škoch, M. Dezortová, E. Švehlíková, M. Hill, J. Brunová, M. Hájek, T. Pelikánová., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:4

Harvested from:

CDK

Metadata only:

false