Optimisation of water treatment conditions with usage of aluminium sulphate and ferric sulphate was made with raw water containing high concentrations of natural aluminium. For optimisation of coagulation conditions here were used the jar tests. The efficiency of aggregation was evaluated with the help of the degree and test of aggregation. In all water samples used, the total aluminium concentration was fractionated into nine forms. The high values of degree of aggregation and high portion of macro-, micro-, and primary particles were attained in optimally treated water samples using both types of coagulants. It contrasts to the portion of nonaggregated particles ranging in optimal treated water only from 3% to 7%. Fractionation of total aluminium proved that the removal efficiency of all Al fractions is very good. and V této práci byly optimalizovány podmínky úpravy vod s přirozeně zvýšeným obsahem hliníku. K optimalizačním testům byla použita sklenicová zkouška. Výsledky byly hodnoceny pomocí testů agregace a stupně agregace. Dále byly u všech vzorků surových i upravených vod provedeny frakcionace celkového hliníku. Výsledky ukázaly, že při optimálních dávkách obou použitých koagulačních činidel je dosahováno vysoké účinnosti agregace. V upravené vodě byly nejvíce zastoupeny mikročástice, makročástice a primární částice hliníku, naopak neagregovaný podíl koagulačního činidla tvořil pouze 3 až 7 %. Při použití obou koagulačních činidel byla zjištěna vysoká účinnost odstranění jednotlivých frakcí hliníku.
a1_Phyllosilicates are classified into the following groups: 1 - Neutral 1:1 structures: the kaolinite and serpentine group. 2 - Neutral 2:1 structures: the pyrophyllite and talc group. 3 - High-charge 2:1 structures, non-expansible in polar liquids: illite and the dioctahedral and trioctahedral micas, also brittle micas. 4 - Low- to medium-charge 2:1 structures, expansible phyllosilicates in polar liquids: smectites and vermiculites. 5 - Neutral 2:1:1 structures: chlorites. 6 - Neutral to weak-char ge ribbon structures, so-called pseudophyllosilicates or hormites: palygorskite and sepiolite (fibrous crystalline clay minerals ). 7 - Amorphous clay minerals. Order-disorder states, polymorphism, polytypism, and inters tratifications of phyllosilicates are influenced by several factors: 1) a chemical micromilieu acting during the crystallization in any environment, including the space of clay pseudomorphs after original rock-forming silicates or volcanic glasses; 2) the accepted thermal energy; 3) the permeability. The composition and properties of parent rocks and minerals in the weathering crusts, the elevation, and topography of source areas and climatic conditions control the in tensity of weathering, erosion, and there sulting assemblage of phyllosilicates to be transported after erosion. The enormously high accumulation of phyllosilicates in the sedimentary lithosphere is primarily conditioned by their high up to extremely high chemical stability in water-rich environments (expressed by index of corrosion, IKO). Clastic material eroded fro m weathering crusts and transported in rivers contains overwhelming amounts of phyllosilicates inherited from original rocks. In geological literature, the newly formed phyllosilicates crystallizing in weathering crusts including soils as dominating global source of argillaceous lutite accumulations in the sedimentary lithosphere have been overestimate for a long time., a2_The dissolution of silicates in different dense rocks under conditions of weathering and the crystallization of newly formed phyllosilicates has been strongly and for long periods influenced by chemical microenvironments within each clay pseudomorph. Coarser fragments of eroded argillaceous rocks and crystals of phyllosilicates from different bedrocks and soils are very sensitive to impacts and pressure from fragments of co-transported harder and denser rocks and minerals in turbulent fluvial and similar currents. This is the most important mechanical phenomenon supporting the enormous accumulation of lutite rocks rich in phyllosilicates in the sedimentary lithosphere. The summarized new observations and interpre tations are stressed in eleven key poin ts. Erosion and water transportation of detrital material are explained in the terms of hydration, softening, swelling, physical disintegration, grinding, milling, abrasion, delamination, dispersi on, and sorting. The deposition of phyllosilicates in different fluid dynamics of streams is expressed by Re and Fr numbers and explained as unflocculated and floccu lated suspensions. Phyllosilicates an d accompanying detrital minerals in recent marine muds covering vast areas of seas and oceans as well as in lacustrine muds correspond with those transpor ted in fluvial suspensions., Jiří Konta., and Obsahuje bibliografické odkazy
Rheological, haemostatic, endothelial and platelet abnormalities appear to play a role in the thrombotic complications of hypertension. This prothrombotic/hypercoagulable state in hypertension may contribute to the increased risk and severity of target organ damage. It can be induced by the activated reninangiotensin system (RAS), with abnormalities in endothelial and platelet function, coagulation and fibrinolysis. Treatment of uncomplicated essential hypertension by RAS targeting antihypertensive therapy could result in a reversal of prothrombotic abnormalities, contributing to a reduction of thrombosis-related complications. Since angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) have two distinct mechanisms of RAS interruption, it is hypothesized that each therapy might have different impact on the prothrombotic state in hypertensive patients. Some studies demonstrate a beneficial effect of both ACE inhibitors and ARBs on prothrombotic state, in addition to their efficacy to normalize elevated blood pressure. The potentially antithrombotic effect of the RAS inhibiting agents may in turn support the preservation of cardiovascular function. Available data may offer an additional explanation for the efficacy of the RAS targeting agents in the prevention of cardiovascular events in patients with atherosclerotic vascular disease., A. Remková, M. Remko., and Obsahuje bibliografii a bibliografické odkazy
The tissue factor (TF) is one of the most important regulators of arterial thrombosis. Because arterial thrombosis is the pathophysiologic background of acute coronary syndrome, the possible impact of blocking the arterial thrombosis on its onset is a challenging problem. The investigations of TF brought a new concept of “cell-based coagulation model” which highlighted the question of blood-borne TF as a source of TF in circulating blood. In this review we summarize essential information on the pathophysiology, molecular structure, expression and distribution of TF and we propose a novel concept of blood-borne TF, suggesting the possibilities of inhibition of the coagulation cascade with newly synthetized drugs., M. A. Malý, P. Tomašov, P. Hájek, P. Blaško, I. Hrachovinová, P. Salaj, J. Veselka., and Obsahuje bibliografii a bibliografické odkazy
Von Willebrand disease is a commonly inherited bleeding disorder caused by defects of von Willebrand factor (vWF). In the most common valve diseases, aortic valve stenosis (AVS) and mitral valve regurgitation (MVR), a bleeding tendency has been described in a number of patients. This has been associated to a high turbulence of blood flow through the compromised valve, promoting degradation of vWF with loss of high-molecular-weight multimers of vWF (HMWM), leading to an acquired von Willebrand syndrome (AvWS). We analysed three groups of patients, one affected by AVS, treated with transcatheter aortic valve implantation (TAVI), the second group of patients affected by MVR, treated with Mitraclip® mitral valve repair. The third group was represented by patients also affected by AVS, but not eligible for TAVI and treated with standard surgery. A fourth group of patients that underwent percutaneous coronary intervention (PCI) with stenting was used as a control. Our results demonstrated that the level of vWF measured as antigen concentration (vWF:Ag) increases in all cohorts of patients after treatment, while in control PCI patients, no modification of vWF:Ag has been registered. Western blot analysis showed only a quantitative loss of vWF in the pre-treatment time, but without significant HMWM modification. The monitoring of the vWF:Ag concentration, but not the quality of HMWM, can indicate the status of blood flow in the treated patients, thus introducing the possibility of using the vWF antigen detection in monitoring the status of replaced or repaired valves.