In the article, the actions of homocysteine (Hcys) and its metabolite - cyclic thioester – homocysteine thiolactone (HTL) on complex process of hemostasis, which regulates the flowing properties of blood, are described. Possible interaction of Hcys and HTL with endothelial cells, blood platelets, plasmatic fibrinogen and plasminogen, as the important major components of hemostasis are also discussed. The modification of hemostatic proteins (N-homocysteinylated or S-homocysteinylated proteins) induced by Hcys or its thiolactone, and links of homocysteine or homocysteine thiolactone to •NO metabolism seem to be the main reason of biotoxicty of homocysteine in cardiovascular diseases., K. Karolczak, B. Olas., and Obsahuje seznam literatury
The tissue factor (TF) is one of the most important regulators of arterial thrombosis. Because arterial thrombosis is the pathophysiologic background of acute coronary syndrome, the possible impact of blocking the arterial thrombosis on its onset is a challenging problem. The investigations of TF brought a new concept of “cell-based coagulation model” which highlighted the question of blood-borne TF as a source of TF in circulating blood. In this review we summarize essential information on the pathophysiology, molecular structure, expression and distribution of TF and we propose a novel concept of blood-borne TF, suggesting the possibilities of inhibition of the coagulation cascade with newly synthetized drugs., M. A. Malý, P. Tomašov, P. Hájek, P. Blaško, I. Hrachovinová, P. Salaj, J. Veselka., and Obsahuje bibliografii a bibliografické odkazy