To calculate the critical depth and the least specific energy of steady non-uniform flows in open channels, one has to solve the polynomial equations. Sometimes, the polynomial equations are too difficult to get them solved. In this study, the theory of algebraic inequality has been used to derive formulas for determining the critical depth and the least specific energy of a steady non-uniform flow in open channel. The proposed method has been assessed using examples. Results using this new method have been compared to those using other conventional methods by engineers and scientists. It is found that the proposed method based on algebraic inequality theory not only makes the calculation process to be easy, but also gives the best calculation results of the critical depth and the least specific energy of a steady nonuniform flow.
During the extraction of coal from thick seams in deep longwall faces, both high in-situ stress and a massive main roof are common. The progressive fracturing in this massive main roof leads to an increase in the front abutment stress and changes in the strain energy of the coal seam which can lead to dynamic disasters such as rockbursts. Based on the mining conditions observed in Panel 5301 of the Xinhe Coal Mine, microseismic (MS) and borehole stress monitoring, along with numerical simulations, was used to propose an evolution law for coal mine roof fracture, front abutment stress, and strain energy. Results indicate that as the roof collapses during the progress of extraction, the transmission point for overburden load moves forward such that the peak front abutment stress advances to 20–25 m in front of the working face. The coal mass within 22–90 m in front of the working face was observed to accumulate 176.2 kJ of strain energy, with the peak strain energy increasing from 80.15 kJ to 136 kJ. The data collected and analyzed in this research provides a theoretical basis for forecasting the location of mining-induced rockburst based on observed fracturing in the main roof.
Autophagy can regulate cell growth, proliferation, and stability of
cell environment. Its dysfunction can be involved in a variety of
diseases. Hydrogen sulfide (H2S) is an important signaling
molecule that regulates many physiological and pathological
processes. Recent studies indicate that H2S plays an important
protective role in many diseases through influencing autophagy,
but its mechanism is not fully understood. This article reviewed
the progress about the effect of H2S on autophagy in diseases in
recent years in order to provide theoretical basis for the further
research on the interaction of H2S and autophagy and the
mechanisms involved.
Ice jams in northern rivers during winter period significantly change the flow conditions due to the extra boundary of the flow. Moreover, with the presence of bridge piers in the channel, the flow conditions can be further complicated. Ice cover often starts from the front of bridge piers, extending to the upstream. With the accumulation of ice cover, ice jam may happen during early spring, which results in the notorious ice jam flooding. In the present study, the concentration of flowing ice around bridge piers has been evaluated based on experiments carried out in laboratory. The critical condition for the initiation of ice cover around bridge piers has been investigated. An equation for the critical floe concentration was developed. The equation has been validated by experimental data from previous studies. The proposed model can be used for the prediction of formation of ice cover in front of a bridge pier under certain conditions.
Terbium (Tb^'*") was ušed as a fluorescence probe in the study of calcium-binding sites on 33 kDa protein of photosystem 2. The fluorescence of Tb^^ was enhanced markedly when bound to the 33 kDa protein, and the non-radiative energy transfer between tryptophan (Trp) residue and Tb^+, bound to the calcium-binding sites on the 33 kDa protein, took plače. According to the Forster non-radiative energy transfer mechanism, the average distance between the bound Tb3+ and Trp residue was found to be 1.05 nm. The pH titration indicated that major groups in the 33 kDa protein, involved in Ca2+ ions binding, were the carboxylic side groups of the glutamic acid and/or aspartic acid.
Regulatory volume decrease (RVD) is essential for the survival of animal cells. The aim of this study was to observe the RVD process in rat ventricular myocytes, and to determine if the KATP channels are involved in the RVD process in these cells. By using reverse transcriptase polymerase chain reaction and Western blot analysis, we demonstrated that there are two types of KATP channels expressed in rat ventricular myocytes: Kir6.1 and Kir6.2. When rat cardiac myocytes were exposed to hypotonic solution, cell volume increased significantly within 15 min and then gradually recovered. This typical RVD process could be inhibited by a Cl– channel blocker (0.5 mM 9-anthracene-carboxylic acid , 9-AC), a K+ channel blocker (5.0 mM CsCl) and a KATP channel blocker glibenclamide (10 μM). Electrophysiological results showed that hypotonic solution activated a whole-cell current, which had similar biophysical characteristics with KATP opener (pinacidil)-induced currents. This current could be blocked by glibenclamide. Our data suggested that the RVD process in rat ventricular myocytes is dependent on the activation of K+ channels, and that KATP channels are involved in this process., L. Shi ... [et al.]., and Obsahuje seznam literatury
The ice jam in a river can significantly change the flow field in winter and early spring. The presence of bridge piers further complicates the hydraulic process by interacting between the ice jam and bridge piers. Using the data collected from experiments in a laboratory flume, the evolution of an ice jam around bridge piers having three different diameters has been investigated in this study. Compared to results without-pier, it was found that the formation of an ice jam in the downstream of bridge pier is faster than that in the upstream. The thickness distribution of the ice jam shows clearly different characteristics in front and behind of bridge piers at different stages of the ice jam.