This study aimed to examine relationships between DHEA(S), anthropometric parameters, oral glucose tolerance test derived data and lipid spectra in a Czech non-diabetic population. 380 healthy volunteers both with and without a family history of diabetes type 2 (DM2) were en rolled into the study (women: n=235, age 28.9±9.4 years, BMI 22.3±4.5 kg/m2, men: n=145, age 32.3±10.0 years, BMI 24.7±3.6 kg/m2). Spearman’s correlations (both without and with the adjustment for age, age and BMI), as well as ANCOVA were used. Non-adjusted data showed many “beneficial” correlations between DHEA(S) and both anthropometric and metabolic variables. Statistical analysis revealed that almost all correlations of DHEA(S) to adiposity and fat distribution in men as well as in women disappeared after the adjustment. There are, however, differences between men and women in the correlation of DHEA(S) to insulin sensitivity and lipid levels. The use of hormonal contraceptives (COC) is also an important factor in this relationship. In men and also in women using COC, DHEA-S after adjustment correlated positively with fasting and stimulated glucose, insulin and C-peptide, and negatively with insulin sensitivity. In this respect, the benefit of DHEA(S) supplementation seems - at least in terms of its alleged antiobesity and antidiabetogenic effects - to be more than controversial., B. Bendlová, J. Vrbíková, M. Hill, M. Vaňková, P. Lukášová, J. Včelák, D. Vejražková, K. Dvořáková, R. Hampl, K. Vondra, L. Stárka., and Obsahuje bibliografii a bibliografické odkazy
The aim of this study was to investigate the effect of 7-oxo-DHEA (dehydroepiandrosterone) on the serum levels of steroid sexual hormones, gonadotropins, lipids and lipoproteins in men. 7-oxo-DHEA was applied onto the skin as a gel to 10 volunteers aged 27 to 72 years for 5 consecutive days. The single dose contained 25 mg 7-oxo-DHEA. Serum concentrations of testosterone, estradiol, cortisol, androstenedione, luteinizing hormone (LH), follicle-stimulating hormone (FSH), sex hormone binding globulin (SHBG), total cholesterol, HDL- and LDL-cholesterol, triglycerides, apolipoprotein A-I and B and lipoprotein(a) were measured before the beginning and shortly after the end of the steroid application. After the treatment, we noted the following significant changes: a decline of testosterone and estradiol levels, increase of LH, HDL-cholesterol and apolipoprotein A-I levels. The decrease of total cholesterol levels was of the borderline significance. A slight but significant increase was found in apolipoprotein B and lipoprotein(a). The most expressive was the fall of the atherogenic index. We suggest that the gel containing 7-oxo-DHEA might be a suitable drug for improving the composition of the steroid and lipid parameters in elderly men., J. Šulcová, M. Hill, Z. Mašek, R. Češka, A.Nováček, R. Hampl, L. Stárka., and Obsahuje bibliografii
Chronické zápalové choroby čreva (inflammatory bowel disease – IBD) vyvolávajú v organizme početné extraintestinálne prejavy, a to v dôsledku spoločnej etiopatogenézy, chronického systémového zápalu, častých porúch výživy a liečby. Jedným z prejavov sú i zmeny endokrinného systému. Interakcia je vzájomná, Crohnova choroba a ulcerózna kolitída spôsobujú funkčné a morfologické zmeny endokrinne aktívnych orgánov, na druhej strane endokrinné funkčné poruchy často negatívne zasahujú do priebehu črevnej choroby. V článku rozoberáme súvis IBD s produkciou pohlavných hormónov a fertilitou, súvis s adrenálnou funkciou, funkciou a morfológiou štítnej žľazy, produkciou rastového hormónu a poruchami rastu u detí, a znížením kostnej denzity. Táto téma nie je v mnohých aspektoch dostatočne preskúmaná a vyžaduje ďalšie analýzy a objasnenia. Kľúčové slová: Crohnova choroba – endokrinný systém – ulcerózna kolitída – zápalové choroby čreva, Inflammatory bowel disease is often accompanied by extraintestinal manifestations due to a common autoimmune etiopathogenesis, chronic systemic inflammation, frequent nutrition deficits, and the treatment. Endocrine system changes belong to manifestations too. Interaction is mutual, Crohn´s disease and ulcerative colitis cause functional and morphological changes of endocrine tissues. On the other hand the endocrine disorders negatively influence the course of bowel disease. In the article we analyze correlation of IBD with gonadal hormone production and fertility, with adrenal function, with the function and morphology of the thyroid, with growth hormone production and growth disorders in children, and with bone mineral density reduction. This topic is not studied enough and needs more analysis and clarification. Key words: Crohn´s disease – endocrine system – inflammatory bowel disease – ulcerative colitis, and Jana Kollerová, Tomáš Koller, Tibor Hlavatý, Juraj Payer
Pánevní kongesce je zvláštní forma chronického žilního onemocnění postihující ženy. Definovaná je jako klinicko‑anatomický syndrom charakterizovaný chronickou pánevní bolestí, perineálním dyskomfortem, mikčními obtížemi a postkoitální bolestí, které jsou způsobeny ovariálním a/nebo pánevním žilním refluxem. Bývá příčinou varixů vulvy, perinea, hýždí a dolních končetin. Těsný vztah je mezi symptomatickými pánevními varixy a renálním syndromem louskáčku. Duplexní ultrasonografie žil břicha, pánve, dolních končetin a vulvoperineální oblasti je hlavní neinvazivní diagnostickou metodou. Magnetická rezonanční venografie nebo jen MR venografie má vysokou senzitivitu v hodnocení pánevní kongesce a může být užita jako screeningové vyšetření nebo v případě nejasného nálezu na ultrazvuku a klinických pochybností. Možnosti medikamentózní terapie jsou omezené, základními léky jsou venofarmaka. Endovaskulární intervence – terapeutická embolizace ovariálních/pánevních žil a implantace ilikokaválního a renálního endovenózního stentu – se stává léčbou první volby u žen s těžkými příznaky, které nereagují na konzervativní terapii., Pelvic congestion is a special form of chronic venous disease in women. This is defined as s syndrome which includes chronic pelvic pain, perineal discomfort, difficulties of micturition, and post‑coital pain in association with ovarian and/or pelvic vein reflux. It may cause vulvar, perineal, gluteal and lower extremity varices. There is a close relation between symptomatic pelvic varices and renal nutcracker syndrome. Duplex ultrasound of abdominal, pelvic and lower extremity veins and vulvoprineal region is the cardinal method of non‑invasive examination. MRI Venography is a highly sensitive technique for evaluating pelvic congestion. It may be used as a screening method or in cases of ambiguous sonographic findings and doubts. Pharmaceutical treatment options are limited, and therapy is based on venoactive drugs. Endovascular intervention – ovarian/iliac veins embolisation therapy and ilio‑caval and renal venous stenting – becomes the first line of treatment for women with severe symptoms, which are resistant to conservative approaches., and Holý M.
Isoflavones are a subgroup of phytoestrogens, natural plant substances with structure similar to 17-β-estradiol and capable of binding to estrogen receptors (ERs). Isoflavones possess higher affinity to ERβ than to ERα and may have a potency to activate both genomic and non-genomic estrogen signaling pathways. In addition, isoflavones interact with the metabolism of steroid hormones. Therefore, the actions of isoflavones are rather complex and may be related to large number of factors, which are not satisfactorily identified yet. Recently, isoflavones have come into focus of interest due to several reports about their positive effect on human health, in particular prevention of hormone-dependent cancers, cardiovascular diseases, osteoporosis, adverse menopausal manifestations and agerelated cognitive decline. Isoflavones may bring new insights into the mechanisms of physiological regulations and increase the possibilities of medical interventions., L. Pilšáková, I. Riečanský, F. Jagla., and Obsahuje bibliografii a bibliografické odkazy