Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men

Title:

Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men

Creator:

Jarmila Šulcová, Hill, M., Mašek, Z., Richard Češka, Nováček, A., Richard Hampl, and Luboslav Stárka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:1ba6c8ab-1700-4f38-873a-f40a4f9b9085
uuid:1ba6c8ab-1700-4f38-873a-f40a4f9b9085
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, pohlavní hormony, lipidy, sex hormones, lipids, transdermal application, 7-oxo-DHEA, LH, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aim of this study was to investigate the effect of 7-oxo-DHEA (dehydroepiandrosterone) on the serum levels of steroid sexual hormones, gonadotropins, lipids and lipoproteins in men. 7-oxo-DHEA was applied onto the skin as a gel to 10 volunteers aged 27 to 72 years for 5 consecutive days. The single dose contained 25 mg 7-oxo-DHEA. Serum concentrations of testosterone, estradiol, cortisol, androstenedione, luteinizing hormone (LH), follicle-stimulating hormone (FSH), sex hormone binding globulin (SHBG), total cholesterol, HDL- and LDL-cholesterol, triglycerides, apolipoprotein A-I and B and lipoprotein(a) were measured before the beginning and shortly after the end of the steroid application. After the treatment, we noted the following significant changes: a decline of testosterone and estradiol levels, increase of LH, HDL-cholesterol and apolipoprotein A-I levels. The decrease of total cholesterol levels was of the borderline significance. A slight but significant increase was found in apolipoprotein B and lipoprotein(a). The most expressive was the fall of the atherogenic index. We suggest that the gel containing 7-oxo-DHEA might be a suitable drug for improving the composition of the steroid and lipid parameters in elderly men., J. Šulcová, M. Hill, Z. Mašek, R. Češka, A.Nováček, R. Hampl, L. Stárka., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:1

Harvested from:

CDK

Metadata only:

false