This study on Alois Klar (1763-1833) focuses mainly on his achievements as a pedagogue and his work for the visually impaired. Methodologically, it draws on Theodor Adorno, Max Horkheimer and Michel Foucault, enabling us to view the evolution of social care as a concomitant of the emerging modern state and integral to its structure. The study presents an analysis of the beginnings of Klar’s Prague institute for the visually impaired against a background of rapid changes in medicine, the scope of the state, and educational thinking. At a time of compulsory school attendance and new approaches to education, when the state demanded the active participation of its subjects/citizens in propagating its aims and the values of society as a whole, the blind and partially sighted were given access to a full and systematic education. We also present data concerning Klar’s educational work and thinking (he taught in Litoměřice and at Prague University), and examine the internal workings of the newly established institute - one of the first of its kind in Europe - and its contacts with the medical discourse of the emerging science of ophthalmology., Marek Fapšo., and Obsahuje bibliografické odkazy
The purpose of the study was to check whether hypoxia of corneal tissue increases the collagenolytic activity due to release of reactive oxygen and nitrogen species. Rats were exposed to hypoxia 10 % O2 for 4, 14, and 21 days. The radical tissue injury was measured by the level of nitrotyrosine and changes in the lipoperoxide-related fluorophores. Collagen protein composition was analyzed by slab gel electrophoresis. The activity of gelatinolytic enzymes was studied using the zymography. The vascularization of the corneas was measured. We found no differences in the corneal tissue in the gel electrophoretic profile of collagenous proteins and gelatinolytic activity between normoxic and hypoxic rats. We did not find any sign of radical tissue injury. There were no changes in the vascularization of corneas after exposition to hypoxia. The environmental 10 % hypoxia does not induce radical tissue injury and an increase of collagenolytic activity in the rat cornea., G. Mahelková, J. Korynta, A. Moravová, J. Novotná, R. Vytášek, J. Wilhelm., and Obsahuje bibliografii a bibliografické odkazy
The aim of our study was to evaluate the efficacy of FK506, mycophenolate mofetil (MM) and aminoguanidine (AMG) on infiltration of macrophages (MPHs), neutrophils (NPHs) and dendritic cells (DC) into corneal grafts during the early phases after transplantation (Tx). Tx was performed in mice (C57BL/10 to BALB/c). Therapy included FK506 (0.2 mg/kg), MM (30 mg/kg) or AMG (0.1 g/kg), started at the day of Tx and was injected i.p. daily. Corneas were excised on the 3rd and 7th day after Tx. Immunohistological evaluation using antibodies against MPHs, NPHs and DC was performed and corneal grafts were assessed in the periphery and in central part of the cornea separately. On the 3rd day after Tx, a massive infiltration of MPHs and NPHs into corneal grafts was revealed; the DC in filtration was lower in all treated groups. Treatment with FK506 and MM led to a significant reduction of NPHs in the centers of the grafts, but not of MPHs. In contrast, AMG significantly reduced MPHs migration into allografts on the third day after Tx, whereas NPHs infiltration has not been attenuated. However, immunosuppressants had no influence on the infiltration of DC during early phases after Tx., P. Bysterská, P. Svozílková, H. Farghali., and Obsahuje bibliografii a bibliografické odkazy
Professor and ophthalmologist Jaromír Kurz treating his patients. Kurz talking about the importance of his work in a segment from Československé filmové noviny (Czechoslovak Film News) 1951, issue no. 13.