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Start Over Creator Černý, V.

2. Experiment ALICE: Štúdium exotických foriem hmoty v zrážkach ťažkých iónov na urýchľovači LHC v CERN

Creator:
Sitár, B., Janik, R., and Černý, V.
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
Univerzita Komenského v Bratislave., Fakulta matematiky, fyziky a informatiky, European Organization for Nuclear Research, fyzika elementárních částic, ionty, elementary particle physics, ions, Slovensko, Slovakia, 6, and 53
Language:
Czech
Description:
B. Sitár, R. Janik, V. Černý.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3. Experiment NA 49: Štúdium vysokoenergetických reakcií na zväzku ťažkých iónov z urýchľovača SPS v CERN

Creator:
Černý, V., Sitár, B., and Kreps, M.
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
Univerzita Komenského v Bratislave., Fakulta matematiky, fyziky a informatiky, European Organization for Nuclear Research, jaderná fyzika, urychlovače, nuclear physics, accelerators, Slovensko, Slovakia, 6, and 53
Language:
Czech
Description:
V. Černý, B. Sitár, M. Kreps a kol.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

4. Experimental endotoxemia induces leukocyte adherence and plasma extravasation within the rat pial microcirculation

Creator:
Zhou, J., Schmidt, M., Johnston, B., Wilfart, F., Whynot, S., Hung, O., Murphy, M., Černý, V., Pavlovic, D., and Lehmann, C.
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, sepse, hematoencefalická bariéra, sepsis, blood-brain barrier, endotoxin, intravital microscopy, 14, and 612
Language:
English
Description:
Disturbance of capillary perfusions due to leukocyte adhesion, disseminated intravascular coagulat ion, tissue edema is critical components in the pathophysiology of sepsis. Alterations in brain microcirculation during sepsis are not clearly understood. The aim of this study is to gain an improved understanding of alterations through direct visualization of brain microcirculations in an experimental endotoxemi a using intravital microscopy (IVM). Endotoxemia was induced in Lewis rats with Lipopolysaccharide (LPS, 15 mg/kg i.v.). The dura mater was removed via a cranial window to expose the pial vessels on the brain surface. Using fluorescence dyes, plasma extravasation of pial venous vessels and leukocyte-endothelial interaction were visualized by intravital microscopy 4 h after LPS administration. Plasma cytokine levels of IL1-β, IL-6, IFN-γ, TNF-α and KC/GRO were evaluated after IVM. A sign ificant plasma extravasation of the pial venous vessels was found in endotoxemia rats compared to control animals. In addition , a significantly increased number of leukocytes adherent to the pial venous endothelium was observed in septic animals. Endotoxemia also induced a significant elevation of plasma cytokine levels of IL1-β, IL-6, IFN-γ, TNF-α and KC/GRO. Endotoxemia increased permeability in the brain pial vessels accompanied by an increase of leukocyte-endothelium interactions and an increase of inflammatory cytokines in the plasma., J. Zhou ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

5. Gastric tonometry and intramucosal pH - theoretical principles and clinical application

Creator:
Černý, V. and Karel Cvachovec
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, šok (lékařství), shock (medicine), diagnostic techniques and procedures, anoxia, intensive care, tonometry, pHi, splanchnic perfusion, 14, and 612
Language:
English
Description:
Gastric or intestinal luminal tonometry is a method for monitoring critically ill patients. It offers an index of the adequacy of aerobic metabolism in a tissue that is particularly sensitive to alterations in its perfusion and oxygenation: the gut mucosa. It is based on the measuring the increase in tissue CO2 production that accompanies anaerobic metabolism. The method simply consists of a balloon in the stomach, which measures intramucosal pCO2. From this measurement and from the arterial bicarbonate concentration gastric intramucosal pH (pHi) can be calculated, assuming that bicarbonate concentration in the gastric mucosal tissue is in equilibrium with systemic arterial bicarbonate. Despite possible clinical benefit from the measurement and the therapy of low pHi values in critically ill patients, the theoretical, experimental and pathophysiological implications for the monitoring of intramucosal acidosis in the gut are not yet fully understood. There are still some open methodological questions crucial for further clinical interpretation., V. Černý, K. Cvachovec., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

6. Microcirculation in pregnancy

Creator:
Abdo, I., George, R. B., Farrag, M., and Černý, V.
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, těhotenství, preeklampsie, diabetes mellitus, pregnancy, preeclampsia, microcirculation, gestational, 14, and 612
Language:
English
Description:
The microcirculation, like all physiological systems undergoes modifications during the course of pregnancy. These changes aid the adaption to the new anatomical and physiological environment of pregnancy and ensure adequate oxygen supply to the fetus. Even though the microcirculation is believed to be involved in major pregnancy related pathologies, it remains poorly understood. The availability of safe and non-interventional technologies enabling scientists to study the intact microcirculation of the pregnant patient will hopefully expand our understanding. In this article we review the physiological changes occurring in the microcirculation during pregnancy and the role of the microcirculation in gestational related pathologies. We will also describe the available techniques for the measurement and evaluation of the microcirculation. Lastly we will highlight the possible fields in which these techniques could be utilized to help provide a clearer view of the microcirculation in the pregnant woman., I. Abdo, R. B. George, M. Farrag, V. Cerny, C. Lehmann., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

7. Mild hypothermia attenuates changes in respiratory system mechanics and modifies cytokine concentration in bronchoalveolar lavage fluid during low lung volume ventilation

Creator:
Dostál, P., Marian Šenkeřík, Radana Pařízková, Bareš, D., Pavel Živný, Helena Živná, and Černý, V.
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, záněty, cytokiny, podchlazení organismu, inflammations, cytokines, hypothermia, rats, mechanical ventilation, 14, and 612
Language:
English
Description:
Hypothermia was shown to attenuate ventilator-induced lung injury due to large tidal volumes. It is unclear if the protective effect of hypothermia is maintained under less injurious mechanical ventilation in animals without previous lung injury. Tracheostomized rats were randomly allocated to non-ventilated group (group C) or ventilated grou ps of normothermia (group N) and mild hypothermia (group H). After two hours of mechanical ventilation with inspiratory fraction of oxygen 1.0, respiratory rate 60 min-1 , tidal volume 10 ml·kg-1 , positive end-expiratory pressure (PEEP) 2 cm H 2 O or immediately after tracheostomy in non-ventilated animals inspiratory pressures were recorded, rats were sacrificed, pressure-volume (PV) curve of respiratory system constructed, bronchoalveolar lavage (BAL) fluid and aortic blood samples obtained. Group N animals exhibited a higher rise in peak inspiratory pressures in comparison to group H animals. Shift of the PV curve to right, higher total protein and interleukin- 6 levels in BAL fluid were observed in normothermia animals in comparison with hypothermia animals and non-ventilated controls. Tumor necrosis factor- α was lower in the hypothermia group in comparison with normothermia and non-ventilated groups. Mild hypothermia attenuated changes in respiratory system mechanics and modified cytokine concentration in bronchoalveolar lavage fluid during low lung volume ventilation in animals without previous lung injury., P. Dostál, M. Šenkeřík, R. Pařízková, D. Bareš, P. Živný, H. Živná, V. Černý., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public