Mild hypothermia attenuates changes in respiratory system mechanics and modifies cytokine concentration in bronchoalveolar lavage fluid during low lung volume ventilation

Title:

Mild hypothermia attenuates changes in respiratory system mechanics and modifies cytokine concentration in bronchoalveolar lavage fluid during low lung volume ventilation

Creator:

Dostál, P., Marian Šenkeřík, Radana Pařízková, Bareš, D., Pavel Živný, Helena Živná, and Černý, V.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:4e3171c7-0190-46df-ad4b-347f5ac761ca
uuid:4e3171c7-0190-46df-ad4b-347f5ac761ca
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, záněty, cytokiny, podchlazení organismu, inflammations, cytokines, hypothermia, rats, mechanical ventilation, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Hypothermia was shown to attenuate ventilator-induced lung injury due to large tidal volumes. It is unclear if the protective effect of hypothermia is maintained under less injurious mechanical ventilation in animals without previous lung injury. Tracheostomized rats were randomly allocated to non-ventilated group (group C) or ventilated grou ps of normothermia (group N) and mild hypothermia (group H). After two hours of mechanical ventilation with inspiratory fraction of oxygen 1.0, respiratory rate 60 min-1 , tidal volume 10 ml·kg-1 , positive end-expiratory pressure (PEEP) 2 cm H 2 O or immediately after tracheostomy in non-ventilated animals inspiratory pressures were recorded, rats were sacrificed, pressure-volume (PV) curve of respiratory system constructed, bronchoalveolar lavage (BAL) fluid and aortic blood samples obtained. Group N animals exhibited a higher rise in peak inspiratory pressures in comparison to group H animals. Shift of the PV curve to right, higher total protein and interleukin- 6 levels in BAL fluid were observed in normothermia animals in comparison with hypothermia animals and non-ventilated controls. Tumor necrosis factor- α was lower in the hypothermia group in comparison with normothermia and non-ventilated groups. Mild hypothermia attenuated changes in respiratory system mechanics and modified cytokine concentration in bronchoalveolar lavage fluid during low lung volume ventilation in animals without previous lung injury., P. Dostál, M. Šenkeřík, R. Pařízková, D. Bareš, P. Živný, H. Živná, V. Černý., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:6

Harvested from:

CDK

Metadata only:

false