Selected adipokines - plasma concentrations and adipose tissue expressions during 24-hour lipid infusion in healthy men

Title:

Selected adipokines - plasma concentrations and adipose tissue expressions during 24-hour lipid infusion in healthy men

Creator:

Jan Kopecký, Eva Krušinová, Marta Klementová, Ludmila Kazdová, Petr Mlejnek, Michal Pravenec, Martin Hill, and Terezie Pelikánová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:61a91acf-0fcc-49b6-91d3-cd52c7d86b64
uuid:61a91acf-0fcc-49b6-91d3-cd52c7d86b64

Subject:

Fyziologie člověka a srovnávací fyziologie, leptin, inzulinová rezistence, insulin resistance, resistin, TNFα, adiponectin, NEFA, triglycerides, lipotoxicity, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Our aim was to assess the reaction of TNFα, resistin, leptin and adiponectin to lipid infusion. Eight healthy subjects underwent a 24-hour lasting infusion of lipid emulsion. Plasma concentrations and expressions of selected cytokines in subcutaneous fat were measured. TNFα plasma concentration did not change during the first 4 hours of hypertriglyceridemia, but a significant increase after 24 hours was detected (p<0.001 for 0; 30; 240 min vs. 24 h). Plasma concentration of resistin significantly increased at 30 min of infusion and remained elevated (p<0.01 for 0 min vs. 30; 240 min; p<0.001 for 0 min vs. 24 h). Plasma concentrations of leptin and adiponectin did not show any significant changes. Although the expression of resistin in the subcutaneous adipose tissue tended to increase, the change was not significant. Expressions of TNFα, leptin and adiponectin were unaffected. In conclusions, our results indicate that acutely induced hyperlipidemia could influence the secretion of TNFα and resistin., J. Kopecký ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:1

Harvested from:

CDK

Metadata only:

false