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12. The effect of vitamin D3 supplementation on intracellular calcium and plasma membrane calcium ATPase activity in early stages of chronic kidney disease
- Creator:
- Morvová, M., Ingrid Lajdová, Viera Spustová, Zvarík, M., and Šikurová, L.
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, vápník, vitamin D, calcium, calcium-ATPase, chronic kidney disease, vitamin D3, 14, and 612
- Language:
- English
- Description:
- Chronic kidney disease (CKD) is associated with increased concentration of intracellular calcium, which is pathological and may lead to irreversible damage of cell functions and structures. The aim of our study was to investigate the impact of 6 months vitamin D3 supplementation (14 000 IU/week) on free cytosolic calcium concentration ([Ca2+]i) and on the plasma membrane calcium ATPase (PMCA) activity of patients with CKD stage 2-3. PMCA activity of patients was also compared to that of healthy volunteers. Vitamin D3 supplementation of CKD patients resulted in the decrease of [Ca2+]i (119.79±5.87 nmol/l vs. 105.36± 3.59 nmol/l, n=14, P<0.001), whereas PMCA activity of CKD patients (38.75±22.89 nmol Pi/mg/h) remained unchanged after vitamin D3 supplementation (40.96±17.74 nmol Pi/mg/h, n=14). PMCA activity of early stage CKD patients before supplementation of vitamin D3, was reduced by 34 % (42.01±20.64 nmol Pi/mg/h) in comparison to healthy volunteers (63.68±20.32 nmol Pi/mg/h, n=28, P<0.001). These results indicate that vitamin D3 supplementation had a lowering effect on [Ca2+]i and negligible effect on PMCA activity in CKD patients., M. Morvová Jr., I. Lajdová, V. Spustová, M. Zvarík, L. Šikurová., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
13. Treatment with cholecalciferol leads to increase of selected semen parameters in young infertile males: results of a 6-month interventional study
- Creator:
- Bartl, Igor, Ondrušová, Miroslava, Kužma, Martin, Jackuliak, Peter, Gažová, Andrea, Kyselovič, Ján, and Payer, Juraj
- Format:
- počítač and online zdroj
- Type:
- model:article and TEXT
- Subject:
- fyziologie člověka, lékařství, vitamin D, human physiology, medicine, Vitamin D receptor, Infertility, Male health, 14, and 612
- Language:
- English
- Description:
- High incidence of infertility along with low vitamin D levels was detected in otherwise healthy young men. The aim is to observe the effect of vitamin D supplementation on semen parameters as assessed by semen analysis in infertile men. In total, 45 men (mean age 36.6 years) in consecutive order were included, of whom 34 finished the study. Subjects were supplemented by vitamin D (cholecalciferol) 2500 IU/day. Vitamin D levels were assessed by HPLC. Semen analysis was performed strictly following 2010 WHO guidelines. Study periods were baseline and month 6. During follow-up, 20 %, 7.4 %, 22 % and 0.7 % increase in serum vitamin D levels, progressive sperm motility, sperm concentration and sperm morphology, respectively, were observed (all p<0.05). At follow-up end, 9 patients (26 %) reached normal sperm parameters of whom 2 fertilized their partner. There was no correlation between vitamin D and semen parameters observed. This study proves that vitamin D supplementation is possibly a modulator of sperm parameters in vitamin D deficient, otherwise healthy men. Although a direct relationship between vitamin D and sperm parameters was not observed obtaining adequate vitamin D levels could likely play a role in the male factor of infertility., Igor Bartl, Miroslava Ondrušová, Martin Kužma, Peter Jackuliak, Andrea Gažová, Ján Kyselovič, Juraj Payer., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
14. Vitamín D a imunita
- Creator:
- Petr Šíma and Bohumil Turek
- Format:
- print, bez média, and svazek
- Type:
- article, text, články, journal articles, model:article, and TEXT
- Subject:
- Biologické vědy, vitamin D, vitaminy, imunita (lékařství), buněčná imunita, autoimunitní nemoci, nádory, vitamins, immunity, cellular immunity, autoimmune diseases, tumors, antiinfekční imunita, humorální imunita, nesdělná onemocnění, non-communicable diseases, 2, and 57/59
- Language:
- Czech
- Description:
- Druhé pokračování o významu vitaminu D pro zdraví člověka (první bylo publikováno v Živě 4/2015) se zabývá jeho úlohou, kterou hraje v imunitě. Donedávna se nepředpokládalo, že by vitamin D mohl podmiňovat také imunitní procesy. Během posledních let se však nashromáždil dostatečný počet experimentálních i klinických studií, které dokládají, že při jeho nedostatečném příjmu dochází k poklesu zejména antiinfekční imunity, a souběžně s tím stoupá také riziko vzniku nesdělných onemocnění. Účelem tohoto sdělení není vyčerpávající informace o mechanismech jeho působen na imunitní systém, ale upozornění pro specialisty i laiky na tuto důležitou, ale prozatím opomíjenou problematiku., This is a further continuation of an 8/2015 article about the importance of vitamin D to the health of human beings (the first was published in Živa 4/2015). The article deals with the role that the vitamin plays in immunity. Until recently, it was not assumed that vitamin D could also be conditional upon immune processes and that it determines the correct function of both natural and adaptive immunity. In recent years, however, a sufficient number of experimental and clinical studies have accumulated, providing evidence that insufficient intake of vitamin D could not only induce decreased immunity to infection but also contribute substantially to an increased risk of non-communicable diseases. The purpose of this communication is not exhaustive information on the mechanisms of vitamin D effects on the immune system, but as an alert to specialists and laymen on hitherto neglected issues., and Petr Šíma, Bohumil Turek.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
15. Vitamin D and thyroid diseases
- Creator:
- Karel Vondra, Luboslav Stárka, and Richard Hampl
- Format:
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- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, vitamin D, nemoci štítné žlázy, autoimunita, rakovina štítné žlázy, thyroid diseases, autoimmunity, thyroid cancer, 14, and 612
- Language:
- English
- Description:
- In this review we summarize recent opinions on the possible role of vitamin D in the risk of thyroid diseases development. It may be concluded from the available data that vitamin D deficiency, particularly levels below 12.5 ng/ml should be considered as an additional, but important risk factor for development of thyroid autoimmunity, both chronic autoimmune thyroiditis and Graves´ disease. A higher risk of Graves´ disease development is also associated with several polymorphisms in the gene encoding for vitamin D binding protein and for the specific receptor of active form of vitamin D - 1,25-(OH)2D3 in the respective target cells. Important for development of thyroid cancer appeared polymorphisms of genes encoding for vitamin D receptors and of genes encoding for the participating hydroxylating enzymes in thyroid tissue, leading to a diminished local 1,25-(OH)2D3 formation capacity with following alteration of antiproliferatory, antiapoptotic and prodifferentiating efficacy of the latter. Whether supplementation with high doses of vitamin D or its analogues possesses preventive or therapeutic effect is an object of intensive studies., K. Vondra, L. Stárka, R. Hampl., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
16. Vitamin D supplementation changed relationships, not levels of metabolic-hormonal parameters in autoimmune thyroiditis
- Creator:
- Karel Vondra, Radovan Bílek, Petr Matucha, Salátová, M., Vosátková, M., Luboslav Stárka, and Richard Hampl
- Format:
- print, bez média, and svazek
- Type:
- article, články, journal articles, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, vitamin D, vitamin D deficiency, autoimmune thyroiditis, supplementation of vitamin D, 14, and 612
- Language:
- English
- Description:
- In women with chronic autoimmune thyroiditis and vitamin D deficiency we have found reference levels of relevant metabolichormonal parameters except for parathormone and total calcium. Three months supplementation with vitamin D (4300 IU/day, cholekalciferol) did not lead to significant changes of investigated hormonal parameters, while the levels of parathormone and calcium reached normal levels. However, a correlation analysis revealed marked changes in mutual relations. First, an inverse correlation of vitamin D with parathormone, insulin secretion (C peptide, insulin) and its efficiency (HOMA IR) disappeared. Relationships of vitamin D to hepatic insulin resistance (insulin/C peptide), to DHEA (both negative), and to DHEAS/DHEA ratio (positive) were newly found. Second, a positive correlation of CRP with insulin secretion remained, while its relation to insulin efficiency (HOMA IR, insulin/ C peptide) was newly observed. Analogical positive correlations appeared also among anti TPO and insulinemia, insulin/C peptide, HOMA IR, and anti Tg to C peptide. A relationship of the CRP with anti TPO became significant (+). Third, out of glucose metabolism parameters only insulin/C peptide and glycemia did not correlate with vitamin D during its deficiency, while after supplementation insulin/ C peptide alone correlated positively with both DHEAS and DHEA, and negatively with vitamin D., K. Vondra, R. Bílek, P. Matucha, M. Salátová, M. Vosátková, L. Stárka, R. Hampl., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
17. Vitamin D, neurosteroids and autism
- Creator:
- Ludmila Máčová, Marie Bičíková, Daniela Ostatníková, Hill, M., and Luboslav Stárka
- Format:
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- Type:
- article, články, journal articles, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, vitamin D, autismus, autoimunita, autism, autoimmunity, neurosteroids, ASD, 14, and 612
- Language:
- English
- Description:
- Vitamin D had been for a long time investigated for its effects on bone metabolism. Recently has been observed that the incidence of some neurodevelopmental disorders (including autism) increases hand in hand with vitamin D deficiency. Indeed, vitamin D was reported to modulate the biosynthesis of neurotransmitters and neurotrophic factors; moreover, its receptor was found in the central nervous system. Vitamin D deficiency was therefore assessed as a risk factor for autism, however the biological mechanism has not yet been revealed. In our review we focused on potential connections among vitamin D, steroids and autism. Potential mechanisms of vitamin D action are also discussed., L. Máčová, M. Bičíková, D. Ostatníková, M. Hill, L. Stárka., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
18. Vitamin D1 versus ecdysteroids: growth effects on cell regeneration and malignant growth in insects are similar to those in humans
- Creator:
- Sláma, Karel
- Format:
- počítač and online zdroj
- Type:
- model:article and TEXT
- Subject:
- insects, ecdysteroids, vitamin D, 20-hydroxyecdysone, cell regeneration, living tissue integrity, insect/human similarity, malignant growth, tumours, D1 avitaminosis, and rachitis
- Language:
- English
- Description:
- Polyhydroxylated derivatives of 6-keto,7-dehydrocholesterol (ecdysteroids) are common constituents of various plants. In 1965, they were accidentally discovered in the search for the insect moulting hormone. These biologically important natural compounds are neither insect hormones nor inducers of insect ecdysis. Due to their strong anabolic, vitamin D-like effects in insects, domestic animals and humans, I propose the use of the arbitrary term vitamin D1 . The present paper describes the effects of vitamin D1 on the growth and regeneration of excised epidermal cells of the tobacco hornworm, Manduca sexta (Sphingidae). The periods of programmed cell death and cell proliferation (histolysis and histogenesis, respectively) exactly coincide in insects with endogenous peaks of increased concentration of vitamin D1 . Epidermal cells communicate with each other, creating a mutually integrated tissue, connected by mechanical, chemical, electrical, ionic or other so far incompletely known factors. After natural cell death, or after the artifi cial removal of some epidermal cells, the neighbouring cells that lose communication integrity, begin to divide mitotically to replace the disconnected part. Cell divisions are arrested as soon as the integrity of the living tissue is established. During insect ontogeny, the application of juvenile hormone causes regenerating epidermal cells to repeat the previous morphogenetic programme (i.e., development of patches of larval tissue on the body of a pupa, or metathetely). Conversely, the application of vitamin D1 (20-hydroxyecdysone) caused the regenerating cells to prematurely execute a future morphogenetic programme (i.e., development of patches of pupal tissue on the body of a larva, or prothetely). Among the key features of insect regeneration, is the arrest of cell divisions when tissues resume living cell-to-cell integrity. This prevents the formation of aberrant groups of cells, or tumours. It is well established that the main physiological systems of insects (e.g., circulatory, respiratory, neuro-endocrine) are structurally and functionally similar to corresponding systems in humans. Thus the basic principles of cell regeneration and the role of vitamin D1 in insects may also be valid for humans. The common vitamins D2 (ergocalciferol) or D3 (cholecalciferol), are exclusively lipid soluble secosterols, which require activation by UV irradiation and hydroxylation in the liver. By contrast, the neglected vitamin D1 is a natural derivative of polyhydroxylated 7-dehydrocholesterol of predominantly plant origin, which is both partly a water and partly a lipid soluble vitamin. It neither requires UV irradiation, nor hydroxylation due to 6 or 7 already built-in hydroxylic groups. Like other vitamins, it enters insect or human bodies in plant food or is produced by intestinal symbionts. Vitamin D1 causes strong anabolic, vitamin D-like effects in domestic animals and in humans. I am convinced that avitaminosis associated with a defi ciency of vitamin D1 in human blood may be responsible for certain hitherto incurable human diseases, especially those related to impaired nerve functions and somatic growth, aberrant cell regeneration or formation of malignant tumours.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
19. Vitamins and brain development
- Creator:
- Ramakrishna, T.
- Format:
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- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, ontogeneze, mozek, malnutrice, vitamin E, vitamin D, vitamin C, kyselina listová, ontogeny, brain, malnutrition, folic acid, neurogenesis, behavior, vitamin B, thiamine, pyridoxine, ribovlafin, vitamin B12, pantothenic acid, 14, and 612
- Language:
- English
- Description:
- T. Ramakrishna. and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public