Treatment with cholecalciferol leads to increase of selected semen parameters in young infertile males: results of a 6-month interventional study

Title:

Treatment with cholecalciferol leads to increase of selected semen parameters in young infertile males: results of a 6-month interventional study

Creator:

Bartl, Igor, Ondrušová, Miroslava, Kužma, Martin, Jackuliak, Peter, Gažová, Andrea, Kyselovič, Ján, and Payer, Juraj

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:a82c4622-60ac-4584-ab9c-1210a456274d
uuid:a82c4622-60ac-4584-ab9c-1210a456274d
issn:0862-8408
doi:10.33549/physiolres.934781

Subject:

fyziologie člověka, lékařství, vitamin D, human physiology, medicine, Vitamin D receptor, Infertility, Male health, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

High incidence of infertility along with low vitamin D levels was detected in otherwise healthy young men. The aim is to observe the effect of vitamin D supplementation on semen parameters as assessed by semen analysis in infertile men. In total, 45 men (mean age 36.6 years) in consecutive order were included, of whom 34 finished the study. Subjects were supplemented by vitamin D (cholecalciferol) 2500 IU/day. Vitamin D levels were assessed by HPLC. Semen analysis was performed strictly following 2010 WHO guidelines. Study periods were baseline and month 6. During follow-up, 20 %, 7.4 %, 22 % and 0.7 % increase in serum vitamin D levels, progressive sperm motility, sperm concentration and sperm morphology, respectively, were observed (all p<0.05). At follow-up end, 9 patients (26 %) reached normal sperm parameters of whom 2 fertilized their partner. There was no correlation between vitamin D and semen parameters observed. This study proves that vitamin D supplementation is possibly a modulator of sperm parameters in vitamin D deficient, otherwise healthy men. Although a direct relationship between vitamin D and sperm parameters was not observed obtaining adequate vitamin D levels could likely play a role in the male factor of infertility., Igor Bartl, Miroslava Ondrušová, Martin Kužma, Peter Jackuliak, Andrea Gažová, Ján Kyselovič, Juraj Payer., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

S99-S107

Source:

Physiological research | 2021 Volume:70 | Number:Supplement 1

Harvested from:

CDK

Metadata only:

false