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Start Over Subject patologie Date Unknown

1. "Aby byla zachována tvář soudruha Gottwalda": Postup a průběh balzamace těla Klementa Gottwalda /

Creator:
Frišhons, Jan,
Type:
studie
Subject:
Smrt. Pohřby. Obyčeje při úmrtí, Gottwald, Klement,, prezidenti českoslovenští, balzamování, patologie, strany politické, KSČ, propaganda, mauzolea, Československo 1948-1969, dějiny zdravotnictví, lékaři, and politické dějiny, politici
Language:
Czech
Description:
"That the Appearance of Comrade Gottwald Be Preserved": The Method and Process of Embalming Klement Gottwald's Body.
Rights:
unknown

2. Algesthesia after epileptic seizure

Creator:
Jan Mareš and Richard Rokyta
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Patologie. Klinická medicína, patologie, epileptické záchvaty, analgezie, krysa obecná, pathology, epileptic seizures, analgesia, Rattus rattus, nociception, flurothyl, postictal analgesia, 14, and 616
Language:
English
Description:
The consequences of epileptic seizures related to postictal inhibition in early postictal period include postictal analgesia. We studied this phenomenon over 96 h following flurothyl-induced seizures in adult male Wistar rats. Nociception of control (no seizure) and seizured groups were tested using the plantar and von Frey hair tests. We determined latency of forepaw and hind paw reactions using plantar tests and the number of von Frey hairs reactions. Shortly after seizures, longer plantar test latencies were seen relative to the control group. Before the seizures the plantar test reaction times were significantly shorter in forepaws than in hind paws. The effect disappeared post-seizure and surprisingly, it also disappeared at the corresponding time in controls; it reappeared after 48 h in the seizure group and after 24 h in controls. Differences in the von Frey hairs test occurred at 5 and 60 min post-seizure, however, these differences could not be explained by limb anatomy; although, different thermal and mechanical nociception mechanisms could be significant. The unexpected reactions in controls could be related to brief social and physical interactions between the two groups. and J. Mareš, R. Rokyta.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3. Effects of diet and age on oxidative damage products in healthy subjects

Creator:
Marica Krajčovičová-Kudláčková, Valachovičová, M., Pauková, V., and Mária Dušinská
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, patologie, oxidační stres, výživa člověka, věk, pathology, oxidative stress, human nutrition, age, antioxidative vitamins, 14, and 612
Language:
English
Description:
Damage of molecules as a consequence of oxidative stress has been implicated in the pathogenes is of chronic diseases related to aging. Diet is a key environmental factor affecting the incidence of many chronic diseases. Antioxidant substances in diet enhance the DNA, lipid and protein protection by increasing the scavenging of free radicals. Products of oxidative damage of DNA (DNA strand breaks with oxidized purines or oxidized pyrimidines), lipids (conjugated dienes of fatty acids) and proteins (carbonyls) in relation to nutrition (vegetarian diet vs. non-vegetarian, traditional mixed diet) were measured in young women aged 20-30 years (46 vegetarians, 48 non-vegetarians) vs. older women aged 60-70 years (33 vegetarians, 34 non-vegetarians). In young subjects, no differences in values of oxidative damage as well as plasma values of antioxidative vitamins (C, β-carotene) were observed between vegetarian and non-vegetarian groups. In older vegetarian group significantly reduced values of DNA breaks with oxidized purines, DNA breaks with oxidized pyrimidines and lipid peroxidation and on the other hand, significantly increased plasma values of vitamin C and β-carotene were found compared to the respective non-vegetarian group. Significant age dependences of measured parameters (increase in all oxidative damage products and decrease in plasma vitamin concentrations in older women) were noted only in non-vegetarians. Vegetarian values of older women vs. young women were similar or non-significantly changed. The results suggest that increase of oxidative damage in aging may be prevented by vegetarian nutrition., M. Krajčovičová-Kudláčková, M. Valachovičová, V. Pauková, M. Dušinská., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

4. Evidence of the use of a horn yoke in the Middle La Tene period, and an analysis of animal finds from La Tene features in the Velké Zboží and Malé Zboží cadasters, central Bohemia

Creator:
Kyselý, René
Type:
article, model:article, and TEXT
Subject:
cattle horn core, pathology, yoke, hornless sheep, Late Iron Age, Bohemia, rohový výběžek tura, patologie, jařmo, bezrohá ovce, mladší doba železná, and Čechy
Language:
Czech
Description:
During archaeological excavations of three La Tène features in 2001 and 2002 at the periphery of the Velké Zboží and Malé Zboží cadasters (Nymburk district), a total of 33 animal bones were obtained. Only domestic mammals were determined in the material: cattle, sheep/goat (of which only sheep is reliably documented), pig, horse and dog. A valuable find from feat. 8 (LT C2-D1) is a horn core from a domestic cattle (Bos taurus), which shows signs of pathology. The pathology comes in the form of a depression on the anterior surface, which leads to the narrowing of the horn. Such pathology is considered to be the result of long-term use of a forehead yoke. The find represents one of a few documented cases of the use of the yoke in prehistory in the territory of today’s Czech Republic. A hornless sheep is documented at another feature. and Při archeologickém výzkumu tří laténských objektů v letech 2001 a 2002 na hranici katastrů Velkého Zboží a Malého Zboží bylo získáno celkem 33 zvířecích kostí. V materiálu byly determinovány pouze domácí druhy savců: tur, ovce/koza (z nich spolehlivě doložena pouze ovce), prase, kůň a pes. Cenným nálezem z obj. 8 (LT C2-D1) je rohový výběžek tura domácího (Bos taurus), který vykazuje patologii. Patologie má charakter deprese na anteriorní ploše, což vede k zúžení rohu. Takováto patologie je pokládána za důsledek déletrvajícího používání nárožního jařma. Nález představuje jeden z mála dokumentovaných dokladů použití jařma v pravěku na území ČR. Z jiného objektu je doložena bezrohá ovce.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

5. Huntingtonova choroba a zvířecí modely

Creator:
Pallová, Daniela, Vochyánová, Klára, Vachútová, Dominika, and Zdenka Ellederová
Type:
article, články, journal articles, model:article, and TEXT
Subject:
Biochemie. Molekulární biologie. Biofyzika, Ústav živočišné fyziologie a genetiky (Akademie věd ČR), molekulární biologie, patologie, Huntingtonova nemoc, molecular biology, pathology, Huntington’s disease, 2, and 577
Language:
Czech
Description:
Huntingtonova choroba (Huntington´s disease, HD) je smrtelné dědičné neurodegenerativní onemocnění s nástupem projevů až v dospělosti. Onemocnění je způsobeno expanzí cytozin-adenin-guanin (CAG) repetic v genu pro protein huntingtin (Htt), který je exprimován ve většině tkání. HD je charakteristická především rozsáhlou degenerací buněk centrální nervové soustavy, ale mutace má velký dopad i na další orgány a tkáně. Mechanismy těchto změn nejsou stále dostatečně popsány. Jednou z nezbytných součástí výzkumu HD jsou zvířecí modely., Huntington's disease (HD) is a fatal inherited neurodegenerative disease with onset of symptoms in adulthood. The disease is caused by the expansion of CAG repeats in the gene for the huntingtin protein, which is expressed in most tissues. HD is characterized by extensive degeneration of the cells of the central nervous system, but the mutation has a large impact on other organs and tissues too. The mechanisms of these changes have not yet been adequately described. Animal models are one of the fundamental approaches in HD research., and Daniela Pallová ... [et al.].
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

7. Konec "nenahraditelného muže". Likvidace R. Heydricha v lékařském kontextu. II. část /

Creator:
Šimůnek, Michal,
Type:
studie
Subject:
Patologie. Klinická medicína, Heydrich, Reinhard,, atentáty, politici němečtí, lékařství, patologie, Československo 1938-1945, dějiny zdravotnictví, lékaři, and odboj, odpor, antifašismus, antikomunismus
Language:
Czech
Description:
The end of the ´irreplaceable man´. The liquidation of Reinhard Heydrich in a medical context. Part II.
Rights:
unknown

8. Limitations in the screening of potentially anti-cryptosporidial agents using laboratory rodents with gastric cryptosporidiosis

Creator:
Andrea Valigurová, Pecková, Radka, Karel Doležal, Bohumil Sak, Dana Květoňová, Martin Kváč, Nurcahyo, Wisnu, and Ivona Foitová
Format:
print, počítač, and online zdroj
Type:
model:article and TEXT
Subject:
patologie, pathology, Cryptosporidium, gastric, oocyst, treatment, 2, and 59
Language:
English
Description:
a1_The emergence of cryptosporidiosis, a zoonotic disease of the gastrointestinal and respiratory tract caused by Cryptosporidium Tyzzer, 1907, triggered numerous screening studies of various compounds for potential anti-cryptosporidial activity, the majority of which proved ineffective. Extracts of Indonesian plants, Piper betle and Diospyros sumatrana, were tested for potential anti-cryptosporidial activity using Mastomys coucha (Smith), experimentally inoculated with Cryptosporidium proliferans Kváč, Havrdová, Hlásková, Daňková, Kanděra, Ježková, Vítovec, Sak, Ortega, Xiao, Modrý, Chelladurai, Prantlová et McEvoy, 2016. None of the plant extracts tested showed significant activity against cryptosporidia; however, the results indicate that the following issues should be addressed in similar experimental studies. The monitoring of oocyst shedding during the entire experimental trial, supplemented with histological examination of affected gastric tissue at the time of treatment termination, revealed that similar studies are generally unreliable if evaluations of drug efficacy are based exclusively on oocyst shedding. Moreover, the reduction of oocyst shedding did not guarantee the eradication of cryptosporidia in treated individuals. For treatment trials performed on experimentally inoculated laboratory rodents, only animals in the advanced phase of cryptosporidiosis should be used for the correct interpretation of pathological alterations observed in affected tissue. All the solvents used (methanol, methanol-tetrahydrofuran and dimethylsulfoxid) were shown to be suitable for these studies, i.e. they did not exhibit negative effects on the subjects. The halofuginone lactate, routinely administered in intestinal cryptosporidiosis in calves, was shown to be ineffective against gastric cryptosporidiosis in mice caused by C. proliferans., a2_In contrast, the control application of extract Arabidopsis thaliana, from which we had expected a neutral effect, turned out to have some positive impact on affected gastric tissue., Andrea Valigurová, Radka Pecková, Karel Doležal, Bohumil Sak, Dana Květoňová, Martin Kváč, Wisnu Nurcahyo, Ivona Foitová., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

9. Mrtvoly a ohledači. Případ faráře Hayneho a vyšetřování sebevražd na Litoměřicku v 1. polovině 19. století /

Creator:
Liepoldová, Tereza
Type:
text and studie
Subject:
Smrt. Pohřby. Obyčeje při úmrtí, sebevraždy, lékařství, vyšetřování, pohřby, patologie, české a československé konference, kongresy, dějiny zdravotnictví, lékaři, and ústavní a právní dějiny
Language:
Czech
Description:
The Case of Pastor Hayne and Suicide Investigation in the District of Litoměřice (Leitmeritz) in the First Half of the 19th Century.
Rights:
unknown