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1. Combination of drugh elevating extracellular adenosine with granulocyte colony-stimulating factor promotes granulopoietic recovery in the murine bone marrow after 5-fluorouracil treatment

Creator:
Michal Hofer, Pospíšil, M., Lenka Weiterová, Vladimír Znojil, Vácha, J., Jiřina Holá, Antonín Vacek, and Iva Pipalová
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, granulocyty, granulocytes, 5-fluorouracil, granulopoiesis, extracellular adenosine, adenosine monophosphate, dipyridamole, granulocyte colony-stimulating factor, 14, and 612
Language:
English
Description:
Combined administration of drugs elevating extracellular adenosine, namely dipyridamole and adenosine monophosphate, together with granulocyte colony-stimulating factor was shown to enhance granulopoietic recovery in the bone marrow of mice treated with 5-fluorouracil. Enhanced regeneration was found both at the level of hematopoietic progenitor cells for granulocytes and macrophages and in the compartment of morphologically recognizable granulocyte precursors. The results might have positive clinical impact. The adjunct use of drugs elevating extracellular adenosine might reduce the cost expenditure of therapy with granulocyte colony-stimulating factor., M. Hofer, M. Pospíšil, L. Weiterová, V. Znojil, J. Vácha, J. Holá, A. Vacek, I. Pipalová., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. Granulocyte and plasma cytokine activity in acute cadmium intoxication in rats

Creator:
Kataranovski, M., Kataranovski, D., Savic, D., Jovčic, G., Bogdanovic, Z., and Jovanovic, T.
Type:
article, model:article, and TEXT
Subject:
cadmium, granulocytes, cytokines, and inflammation
Language:
English
Description:
Changes in the number and ex vivo function of peripheral blood neutrophils were investigated following intraperitoneal administration of cadmium-chloride in rats. Besides a dose-dependent increase in the number of peripheral blood neutrophils, changes were found in the functional state of isolated polymorphonuclear leukocytes (PMNs). Increased spontaneous adhesion and activation, and TNF activity in a conditioned medium were observed in cultures of granulocytes in comparison to granulocytes from control (saline-treated) animals. Increased levels of plasma activity of inflammatory cytokines, tumor necrosis factor (TNF) and interleukin-6 (IL-6) were noted following cadmium administration. Cytological signs of pulmonary inflammation were revealed histologically and the majority of neutrophils recovered from the lungs by enzyme digestion exhibited a capacity of nitroblue tétrazolium (NBT) reduction. Our data demonstrate that acute cadmium intoxication leads to a systemic inflammatory response characterized by numerical and functional changes in the granulocyte compartment and to increased levels of inflammation-related cytokine activity in the circulation. Correlations between the increased number of peripheral blood neutrophils and IL-6 plasma activity (r = 0.776, p< 0.00001) and the number of neutrophils recovered from the lung tissue (r = 0.893, p< 0.00001) suggested that systemic cadmium-induced inflammation might be involved in the pulmonary toxicity of cadmium.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3. Meloxicam, an inhibitor of cyclooxygenase-2, increases the level of serum G-CSF and might be usable as an auxiliary means in G-CSF therapy

Creator:
Hofer, M., Milan Pospíšil, Vladimír Znojil, Jiřina Holá, Antonín Vacek, and Denisa Štreitová
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, patologická fyziologie, krvetvorba, cyklooxygenáza 2, granulocyty, pathological physiology, hematopoiesis, cyclooxygenase 2, granulocytes, meloxicam, granulocyte colony-stimulating factor, treatment of myelosuppression, 14, and 612
Language:
English
Description:
Hematopoiesis-modulating action of meloxicam, a cyclooxygenase-2 inhibitor, has been evaluated in mice. Increased serum level of granulocyte colony-stimulating factor (G-CSF) after meloxicam administration has been found in sublethally γ-irradiated animals. In further experiments hematopoiesis-stimulating effects of meloxicam and G-CSF given alone or in combination have been investigated. Granulocyte/macrophage progenitor cells counts were used to monitor these effects. Meloxicam and exogenous G-CSF did not act synergistically when given in combination, but could be mutually substituted during their repeated administration. The results suggest a promising possibility of using meloxicam as an auxiliary drug reducing the high costs of G-CSF therapy of myelosuppression., M. Hofer, M. Pospíšil, V. Znojil, J. Holá, A. Vacek, D. Štreitová., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public