Meloxicam, an inhibitor of cyclooxygenase-2, increases the level of serum G-CSF and might be usable as an auxiliary means in G-CSF therapy

Title:

Meloxicam, an inhibitor of cyclooxygenase-2, increases the level of serum G-CSF and might be usable as an auxiliary means in G-CSF therapy

Creator:

Hofer, M., Milan Pospíšil, Vladimír Znojil, Jiřina Holá, Antonín Vacek, and Denisa Štreitová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9fe434ec-1224-4c21-a39e-157504dbe139
uuid:9fe434ec-1224-4c21-a39e-157504dbe139
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, patologická fyziologie, krvetvorba, cyklooxygenáza 2, granulocyty, pathological physiology, hematopoiesis, cyclooxygenase 2, granulocytes, meloxicam, granulocyte colony-stimulating factor, treatment of myelosuppression, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Hematopoiesis-modulating action of meloxicam, a cyclooxygenase-2 inhibitor, has been evaluated in mice. Increased serum level of granulocyte colony-stimulating factor (G-CSF) after meloxicam administration has been found in sublethally γ-irradiated animals. In further experiments hematopoiesis-stimulating effects of meloxicam and G-CSF given alone or in combination have been investigated. Granulocyte/macrophage progenitor cells counts were used to monitor these effects. Meloxicam and exogenous G-CSF did not act synergistically when given in combination, but could be mutually substituted during their repeated administration. The results suggest a promising possibility of using meloxicam as an auxiliary drug reducing the high costs of G-CSF therapy of myelosuppression., M. Hofer, M. Pospíšil, V. Znojil, J. Holá, A. Vacek, D. Štreitová., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:2

Harvested from:

CDK

Metadata only:

false