Combination of drugh elevating extracellular adenosine with granulocyte colony-stimulating factor promotes granulopoietic recovery in the murine bone marrow after 5-fluorouracil treatment

Title:

Combination of drugh elevating extracellular adenosine with granulocyte colony-stimulating factor promotes granulopoietic recovery in the murine bone marrow after 5-fluorouracil treatment

Creator:

Michal Hofer, Pospíšil, M., Lenka Weiterová, Vladimír Znojil, Vácha, J., Jiřina Holá, Antonín Vacek, and Iva Pipalová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bfbc37be-6a12-46a5-83bb-ba056d6fdef4
uuid:bfbc37be-6a12-46a5-83bb-ba056d6fdef4
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, granulocyty, granulocytes, 5-fluorouracil, granulopoiesis, extracellular adenosine, adenosine monophosphate, dipyridamole, granulocyte colony-stimulating factor, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Combined administration of drugs elevating extracellular adenosine, namely dipyridamole and adenosine monophosphate, together with granulocyte colony-stimulating factor was shown to enhance granulopoietic recovery in the bone marrow of mice treated with 5-fluorouracil. Enhanced regeneration was found both at the level of hematopoietic progenitor cells for granulocytes and macrophages and in the compartment of morphologically recognizable granulocyte precursors. The results might have positive clinical impact. The adjunct use of drugs elevating extracellular adenosine might reduce the cost expenditure of therapy with granulocyte colony-stimulating factor., M. Hofer, M. Pospíšil, L. Weiterová, V. Znojil, J. Vácha, J. Holá, A. Vacek, I. Pipalová., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:5

Harvested from:

CDK

Metadata only:

false