The Florentine historian and politician, Francesco Guicciardini, played a key role in Renaissance culture and his works contributed to the heated debate between the Catholic and Reformed churches. A diplomat and adviser to the Medici Family and the Papacy, his work left a crucial mark during his lifetime, and between the sixteenth and seventeenth centuries his texts made the long journey through Europe, meeting with considerable appreciation. Leading thinkers, editors, printers, kings and military leaders published,and read his works, and this paper aims to shed light upon this important moment in the dissemination of Renaissance culture.