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Start Over Creator Tomáš Kučera

2. Associations between cardiac fibrosis and permanent atrial fibrillation in advanced heart failure

Creator:
Bashar Aldhoon, Tomáš Kučera, Smorodinová, M., Jindřich Martínek, Vojtěch Melenovský, and Josef Kautzner
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, heart failure, atrial fibrillation, atrial fibrosis, extracellular matrix, transforming growth factor, connective tissue growth factor, 14, and 612
Language:
English
Description:
Atrial fibrosis is considered as the basis in the development of long-standing atrial fibrillation (AF). However, in advanced heart failure (HF), the independent role of fibrosis for AF development is less clear since HF itself leads to atrial scarring. Our study aimed to differentiate patients with AF from patients without AF in a population consisting of patients with advanced HF. Myocardial samples from the right atrial and the left ventricular wall were obtained during he art transplantation from the explanted hearts of 21 male patients with advanced HF. Long- standing AF was present in 10 of them and the remaining 11 patients served as sinus rhythm controls. Echocardiographic and hemodynamic measurements were recorded prior to heart transplantation. Collagen volume fraction (CVF), transforming growth factor-beta (TGF- β ), and connective tissue growth factor (CTGF) expression in myocardial specimens were assessed histologically and immunohistochemically. The groups were well matched according to age (51. 9±8.8 vs. 51.3±9.3 y) and co- morbidities. The AF group had high er blood pressure in the right atrium (13.6±7.7 vs. 6.0±5.0 mmHg; p=0.02), larger left atrium diameter (56.1±7.7 vs. 50±5.1 mm; p=0.043), higher left atrium wall stress (18.1±2.1 vs. 16.1±1.7 kdynes/m 2 ; p=0.04), and longer duration of HF (5.0±2.9 vs. 2.0±1.6 y, p=0.008). There were no significant differences in CVF (p=0.12), in CTGF (p=0.60), and in TGF- β expression (p=0.66) in the atrial myocardium between the two study groups. In conclusions, in advanced HF, atrial fibrosis expressed by CVF is invariably present regardless of occurrence of AF. In addition to atrial wall fibrosis, increased wall stress might contribute to AF development in long-standing AF., B. Aldhoon, ... [et al.]., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3. Jak rozpoznat reliktní druh? Příběh odhalení vzácné rašeliništní houby šupinovky Henningsovy

Creator:
Jan Holec and Tomáš Kučera
Format:
bez média and svazek
Type:
article, text, články, journal articles, model:article, and TEXT
Subject:
Biologické vědy, biologie, ohrožené druhy, houby, rašeliniště, biology, mushrooms, endangered species, peatlands, Borkovická blata (Česko : přírodní rezervace), Borkovice Region (Czechia), šupinovka Henningsova, reliktní rašeliniště, rašeliništní houby, Pholiota henningsii, 2, and 57/59
Language:
Czech
Description:
Analyzovali jsme stanoviště a rozšíření houby šupinovky Henningsovy (Pholiota henningsii) v Evropě, kde je známa z Holandska, Akvitánie, Pařížské pánve, Massiv Central, úpatí Pyrenejí a Alp ve Francii a Švýcarsku, třetihorních pánví v Rakousku a jižních Čechách, z Mazurských jezer v Polsku, ostrova Sjaelland v Dánsku a ostrovů poblíž Stockholmu ve Švédsku. Všude je velmi vzácná a v mnoha zemích je zařazena na červených seznamech ohrožených druhů hub. Roste na slatinách, přechodových rašeliništích i vrchovištích, jak živinami bohatých, tak chudých. Váže se na lokality a oblasti s dlouhodobou (tisíciletou) historií otevřených rašelinišť ležících v blízkosti vodních nádrží. V ČR byly tři historické lokality doplněny v roce 2012 o dvě nové. Dlouhodobá mozaika lesa a bezlesí se zdá být hlavní podmínkou pro přežívání tohoto druhu reliktních stanovišť., The occurrence of the rare fungus Pholiota henningsii has been analysed in Europe. It is known from the Netherlands, the Parisian and Aquitanian basins, the Massif Central, and the foothils of the Pyrenées and Alps in France, Switzerland and Austrian Terciary basins, with numerous mires, in southern Bohemia, the Mazury lakes in Poland, Sjaelland island in Denmark and the island region near Stockholm in Sweden. In many countries it is included in Red Lists of endangered species. The fungus occurs in spring fens, transitional mires and raised bogs, both nutrient rich and oligotrophic. It is confined to localities with long term (i.e. millennia-long) mire non-forest continuity, in the vicinity of open water bodies up to the present. In the Czech Republic three historical sites were completed by two new localities in 2012. A temperate and forest - treeless mire mosaic seems to be the conditional factor for the long-term persistence of this relict species., and Jan Holec, Tomáš Kučera.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

4. Karel Kuča (ed.), Věra Kučová, Alena Salašová, Ivan Vorel, Martin Weber a kolektiv: Krajinné památkové zóny České republiky

Creator:
Tomáš Kučera
Format:
print, bez média, and svazek
Type:
article, recenze, model:article, and TEXT
Subject:
Biologické vědy, krajinné památkové zóny, ochrana krajiny, kulturní krajina, landscape monument zones, landscape protection, cultural landscape, 2, and 57/59
Language:
Czech
Description:
[autor recenze] Tomáš Kučera.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

5. Krajinné souvislosti - prostor pro multidisciplinární výuku?

Creator:
Tomáš Kučera and Erika Smrtová
Format:
bez média and svazek
Type:
article, text, články, journal articles, model:article, and TEXT
Subject:
Životní prostředí a jeho ochrana, krajina, studium a výuka, předmětová didaktika, environmentální výchova a vzdělávání, landscape, study and teaching, teaching school subjects, environmental education, multidisciplinární výuka, 2, and 502
Language:
Czech
Description:
Tomáš Kučera, Erika Smrtová.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

6. Na krajinu s kompaktem?: fotografujeme vegetaci a krajinu digitálně

Creator:
Tomáš Kučera
Format:
print, bez média, and svazek
Type:
article, text, články, journal articles, model:article, and TEXT
Subject:
Biologické vědy, vegetace, krajina, krajinářská fotografie, vědecká fotografie, fotografování, digitální fotografie, vegetation, landscape photography, landscape, scientific photography, photography, digital photography, fotografie přírody, fotografie vegetace, 2, and 57/59
Language:
Czech
Description:
Dokumentační fotografie vegetace a krajiny má specifické požadavky na prosvětlené snímky zachycující detailní kresbu tvarů listů a přesné barvy květů. V digitální fotografii dlouhou dobu chyběly kvalitní fotoaparáty kompaktních rozměrů, které byly navíc velmi drahé. Naštěstí rychlý vývoj technologií přinesl takové možnosti snímání, které jsou prakticky už na úrovni tradičních fotopřístrojů středního formátu., Vegetation and landscape documentation photography have special requirements for clear pictures with details of leaf shapes and flower colors. Hence for a long time in digital photography there was a lack of high quality compact cameras, which in any case were very expensive. Fortunately, rapid technological developments have provided options comparable with the middle-format cameras of the past., and Tomáš Kučera.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

8. Sirtuin 1 modulation in rat model of acetaminophen-induced hepatotoxicity

Creator:
Wojnarová, L., Nikolína Kutinová-Canová, Hassan Farghali, and Tomáš Kučera
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie, játra, physiology, liver, SIRT1, resveratrol, acetaminophen, CAY10591, 14, and 612
Language:
English
Description:
Sirtuin 1 (SIRT1) is involved in important biological processes such as energy metabolism and regulatory functions of the cell cycle, apoptosis, and inflammation. Our previous studies have shown hepatoprotective effect of polyphenolic compound resveratrol, which is also an activator of SIRT1. Therefore, the aim of our present study was to clarify the role of SIRT1 in process of hepatoprotection in animal model of drug-induced liver damage. Male Wistar rats were used for both in vivo and in vitro studies. Hepatotoxicity was induced by single dose of acetaminophen (APAP). Some rats and hepatocytes were treated by resveratrol or synthetic selective activator of sirtuin 1 (CAY10591). The degree of hepatotoxicity, the activity and expression of the SIRT1 were determined by biochemical, histological and molecular-biological assessments of gained samples (plasma, liver tissue, culture media and hepatocytes). Resveratrol and CAY attenuated APAP-induced hepatotoxicity in vivo and in vitro. Moreover, both drugs enhanced APAPreduced SIRT1 activity. Our results show that modulation of the SIRT1 activity plays a role in hepatoprotection. Synthetic activators of SIRT1 would help in understanding the role of SIRT1 and are therefore a major boost towards the search for specific treatment of liver disease., L. Wojnarová, N. Kutinová Canová, H. Farghali, T. Kučera., and Obsahuje bibliografii
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public