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Start Over Subject zánět--farmakoterapie

2. Pistacia terebinthus coffee protects against thioacetamide-induced liver injury in rats

Creator:
Bahcecioglu, Ibrahim Halil, Ispiroglu, Murat, Tuzcu, Mehmet, Orhan, Cemal, Ulas, Mustafa, Demirel, Ulvi, Yalniz, Mehmet, Özercan, Ibrahim H., Ilhan, Necip, and Sahin, Kazim
Format:
print, text, and regular print
Type:
model:article, article, Text, časopisecké články, and TEXT
Subject:
zvířata, antioxidancia--farmakologie, modely nemocí na zvířatech, zánět--farmakoterapie, játra--účinky léků--metabolismus--patologie, experimentální cirhóza jater--chemicky indukované--metabolismus--patofyziologie--prevence a kontrola, mužské pohlaví, noxy--toxicita, oxidační stres--účinky léků, Pistacia, krysy, potkani Sprague-Dawley, Teas, Herbal, thioacetamid--toxicita, transformující růstový faktor beta--metabolismus, výsledek terapie, and triterpeny--farmakologie
Language:
English
Description:
AIM/BACKGROUND: Pistacia terebinthus is used as a coffee substitute in the East and Southern Anatolia regions of Turkey. It contains unsaturated fatty acids, tocopherols, polyphenols and carotenoids. P. terebinthus has anti-inflammatory and potential antioxidant activity. In this study we evaluated the protective effects of P. terebinthus coffee (PTC) on thioacetamide (TAA)-induced liver injury in rats. MATERIALS AND METHODS: Twenty-eight male Sprague-Dawley rats were equally randomized into four groups. Chronic liver injury was induced with TAA (100 mg/kg i.p. three times weekly). The first group of rats served as control and received only tap water (G1), and the remaining groups of rats received PTC, p.o (G2); TAA (G3); TAA plus PTC, p.o (G4), respectively. RESULTS: After 8 weeks, PTC intake significantly reduced fibrosis/inflammation scores (p PTC intake reduced transforming growth factor beta (TGF-β) concentrations in the liver (p PTC intake. DISCUSSION AND CONCLUSION: PTC intake provided beneficial effects against TAA-induced liver injury in rats. PTC probably suppresses the proinflammatory cytokines through NF-κB signaling pathway. and I. H. Bahcecioglu, M. Ispiroglu, M. Tuzcu, C. Orhan, M. Ulas, U. Demirel, M. Yalniz, I. H. Özercan, N. Ilhan, K. Sahin
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public