Pistacia terebinthus coffee protects against thioacetamide-induced liver injury in rats

Title:

Pistacia terebinthus coffee protects against thioacetamide-induced liver injury in rats
Pistacia terebinthus coffee protects against thioacetamide-induced liver injury in rats

Creator:

Bahcecioglu, Ibrahim Halil, Ispiroglu, Murat, Tuzcu, Mehmet, Orhan, Cemal, Ulas, Mustafa, Demirel, Ulvi, Yalniz, Mehmet, Özercan, Ibrahim H., Ilhan, Necip, and Sahin, Kazim

Contributor:

Bahcecioglu, Ibrahim Halil, Ispiroglu, Murat, Tuzcu, Mehmet, Orhan, Cemal, Ulas, Mustafa, Demirel, Ulvi, Yalniz, Mehmet, Özercan, Ibrahim H., Ilhan, Necip, and Sahin, Kazim

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc15040064-482e3aa5-72c0-4372-b44b-f6e89ec1ef1b
uuid:bmc15040064-482e3aa5-72c0-4372-b44b-f6e89ec1ef1b
local:bmc15040064
http://actamedica.lfhk.cuni.cz/
doi: 10.14712/18059694.2015.94
local: bmc15040064

Subject:

zvířata, antioxidancia--farmakologie, modely nemocí na zvířatech, zánět--farmakoterapie, játra--účinky léků--metabolismus--patologie, experimentální cirhóza jater--chemicky indukované--metabolismus--patofyziologie--prevence a kontrola, mužské pohlaví, noxy--toxicita, oxidační stres--účinky léků, Pistacia, krysy, potkani Sprague-Dawley, Teas, Herbal, thioacetamid--toxicita, transformující růstový faktor beta--metabolismus, výsledek terapie, and triterpeny--farmakologie

Type:

model:article, article, Text, časopisecké články, and TEXT

Format:

print, text, and regular print

Description:

AIM/BACKGROUND: Pistacia terebinthus is used as a coffee substitute in the East and Southern Anatolia regions of Turkey. It contains unsaturated fatty acids, tocopherols, polyphenols and carotenoids. P. terebinthus has anti-inflammatory and potential antioxidant activity. In this study we evaluated the protective effects of P. terebinthus coffee (PTC) on thioacetamide (TAA)-induced liver injury in rats. MATERIALS AND METHODS: Twenty-eight male Sprague-Dawley rats were equally randomized into four groups. Chronic liver injury was induced with TAA (100 mg/kg i.p. three times weekly). The first group of rats served as control and received only tap water (G1), and the remaining groups of rats received PTC, p.o (G2); TAA (G3); TAA plus PTC, p.o (G4), respectively. RESULTS: After 8 weeks, PTC intake significantly reduced fibrosis/inflammation scores (p PTC intake reduced transforming growth factor beta (TGF-β) concentrations in the liver (p PTC intake. DISCUSSION AND CONCLUSION: PTC intake provided beneficial effects against TAA-induced liver injury in rats. PTC probably suppresses the proinflammatory cytokines through NF-κB signaling pathway. and I. H. Bahcecioglu, M. Ispiroglu, M. Tuzcu, C. Orhan, M. Ulas, U. Demirel, M. Yalniz, I. H. Özercan, N. Ilhan, K. Sahin

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové) Universitas Carolina, Facultas Medica Hradec Králové--MED00010947

Source:

Acta medica (Hradec Králové) | 2015 Volume:58 | Number:2

Harvested from:

CDK

Metadata only:

false

Date:

2015