Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium

Title:

Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium

Creator:

Ognjanović, B. I., Pavlović, S. Z., Maletić, S. D., Žikić, R. V., Štajn, A. Š., Radojičić, R. M., Saičić, Z. S., and Petrović, V. M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:c982f72c-dda2-4442-baab-e00204a480d3
uuid:c982f72c-dda2-4442-baab-e00204a480d3
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, vitamin E, kadmium, krev, cadmium, blood, lipid peroxides, antioxidant defense system, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The effects of acute exposure to cadmium (Cd) on the blood antioxidant defense system, lipid peroxide concentration and hematological parameters, as well as the possible protective role of vitamin E were studied. Male Wistar albino rats (3 months old) were treated with cadmium (0.4 mg Cd/kg b.m., i.p., 24 h before the experiment) or with vitamin E + Cd (20 IU Vit E/kg b.m., i.m., 48 h + 0.4 mg Cd/kg b.m., i.p., 24 h before the experiment). The hematological parameters were assessed: red blood cell counts, hematocrit value and hemoglobin concentration were significantly decreased in the blood of Cd-treated rats. Intoxication with cadmium was also followed by significantly increased lipid peroxide concentrations. We also observed increased activity of antioxidant defense enzymes: copper zinc containing superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase as well as concentrations of non-enzymatic components of antioxidant defense system: reduced glutathione, vitamin C and vitamin E. Pretreatment with vitamin E exhibited a protective role on the toxic effects of cadmium on the hematological values, lipid peroxide concentration as well as on enzymatic and non-enzymatic components of antioxidant defense system., B. I. Ognjanović, S. Z. Pavlović, S. D. Maletić, R. V. Žikić, A. Š. Štajn, R. M. Radojičić, Z. S. Saičić, V. M. Petrović., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2003 Volume:52 | Number:5

Harvested from:

CDK

Metadata only:

false