Chromogranin A, a member of neuroendocrine secretory proteins as a selective marker for laboratory diagnosis of pheochromocytoma

Title:

Chromogranin A, a member of neuroendocrine secretory proteins as a selective marker for laboratory diagnosis of pheochromocytoma

Creator:

Radovan Bílek, Libor Šafařík, Vanda Ciprová, Petr Vlček, and Lidka Lisá

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:c459bc98-8de8-44cf-ab15-1d12b478e89a
uuid:c459bc98-8de8-44cf-ab15-1d12b478e89a
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, endokrinologie, feochromocytomy, krevní plazma, endocrinology, pheochromocytoms, blood plasma, chromogranin A, radioimmunometric assay, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The function of chromogranin A (CGA) is reviewed, and the radioimmunometric determination of plasma CGA was evaluated as a marker of pheochromocytoma using a comparison of pheochromocytoma patients immediately before surgery (group P, n=25, 635±451 ng/ml) with other groups of patients, i.e. pheochromocytoma patients approximately 1 year after removal of tumor (group PP, n=13, 69±33 ng/ml), medullary thyroid carcinoma patients (group M, n=22, 106±59 ng/ml), congenital adrenal hyperplasy patients (n=33, 65±40 ng/ml), and controls (n=31, 66±29 ng/ml). A CGA level above cut off value 130 ng/ml was found in 24 of 25 patients in group P, 1 (relapse) of 13 patients in group PP, and 4 of 22 patients in group M. In the group P we found a significant association between the size of the tumors removed and plasma CGA concentrations (p=0.0016), and also a significant (p=0.0016) relationship between plasma CGA concentrations and PASS score rating the malignity of pheochromocytoma. We can conclude that plasma CGA concentration as determined by radioimmunometric assay (which is simple without the necessity of special laboratory equipment) is an effective marker of pheochromocytoma with association to malignity and tumor mass., R. Bílek, L. Šafařík, V. Ciprová, P. Vlček, L. Lisá., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false