CD200/CD200R paired potent inhibitory molecules regulating immune and inflammatory responses

Title:

CD200/CD200R paired potent inhibitory molecules regulating immune and inflammatory responses
CD200/CD200R paired potent inhibitory molecules regulating immune and inflammatory responses. part I. CD200/CD200R structure, activation, and function
CD200/CD200R structure, activation, and function

Creator:

Holmannová, Drahomíra, Koláčková, Martina, Kondělková, Kateřina, Kuneš, Pavel, Krejsek, Jan, and Andrýs, Ctirad

Contributor:

Holmannová, Drahomíra, Koláčková, Martina, Kondělková, Kateřina, Kuneš, Pavel, Krejsek, Jan , 1958-, and Andrýs, Ctirad , 1962-

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc12017003-bcca69fb-95d7-4480-ac7d-64395a00af2e
uuid:bmc12017003-bcca69fb-95d7-4480-ac7d-64395a00af2e
local:bmc12017003
http://www.lfhk.cuni.cz/Data/files/Casopisy/2012/2012_12.pdf
local: bmc12017003

Subject:

zvířata, antigeny CD--fyziologie, antigeny povrchové--fyziologie, lidé, imunita--fyziologie, zánět--patofyziologie, receptory buněčného povrchu--fyziologie, and signální transdukce

Type:

model:article, article, Text, statistics, přehledy, práce podpořená grantem, and TEXT

Format:

braille, electronic resource, remote, and elektronický zdroj

Description:

CD200/CD200R are highly conserved type I paired membrane glycoproteins that belong to the Ig superfamily containing a two immunoglobulin‑like domain (V, C). CD200 is broadly distributed in a variety of cell types, whereas CD200R is primarily expressed in myeloid and lymphoid cells. They fulfill multiple functions in regulating inflammation. The interaction between CD200/CD200R results in activation of the intracellular inhibitory pathway with RasGAP recruitment and thus contributes to effector cell inhibition. It was confirmed that the CD200R activation stimulates the differentiation of T cells to the Treg subset, upregulates indoleamine 2,3‑dioxygenase activity, modulates cytokine environment from a Th1 to a Th2 pattern, and facilitates an antiinflammatory IL‑10 and TGF‑β synthesis. CD200/CD200R are required for maintaining self‑tolerance. Many studies have demonstrated the importance of CD200 in controlling autoimmunity, inflammation, the development and spread of cancer, hypersensitivity, and spontaneous fetal loss., Drahomíra Holmannová, Martina Koláčková, Kateřina Kondělková, Pavel Kuneš, Jan Krejsek, Ctirad Andrýs, and Literatura 46

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové)--MED00010947

Source:

Acta medica (Hradec Králové) | 2012 Volume:55 | Number:1

Harvested from:

CDK

Metadata only:

false

Date:

2012