A periadventitial sirolimus-releasing mesh decreased intimal hyperplasia in a rabbit model

Title:

A periadventitial sirolimus-releasing mesh decreased intimal hyperplasia in a rabbit model

Creator:

Ivo Skalský, Elena Filová, Ondrej Szárszoi, Martin Pařízek, Lytvynets, A., Jana Malušková, Alena Lodererová, Eduard Brynda, Věra Lisá, Burdíková, Z., Martin Čapek, Jan Pirk, and Lucie Bačáková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:a3daf891-1789-4110-81d5-e531a09583da
uuid:a3daf891-1789-4110-81d5-e531a09583da

Subject:

Fyziologie člověka a srovnávací fyziologie, stenózy, hyperplazie, stenoses, hyperplasia, intimal hyperplasia, controlled drug release, perivascular mesh, rapamycin, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Autologous vein grafts used as aortocoronary bypasses are often prone to intimal hyperplasia, which results in stenosis and occlusion of the vein. The aim of this study was to prevent intimal hyperplasia using a newly developed perivascular system with sustained release of sirolimus. This system of controlled drug release consists of a polyester mesh coated with a copolymer of L-lactic acid and ε -caprolactone that releases sirolimus. The mesh is intended for wrapping around the vein graft during surgery. The mesh releasing sirolimus was implanted in periadventitial position onto arteria carotis communis of rabbits, and neointimal hyperplasia was then assessed. We found that implanted sirolimus-releasing meshes reduced intima thickness by 47±10 % compared to a vein graft after 3 weeks. The pure polyester mesh decreased vein intima thickness by 35±9 %. Thus, our periadventitial system for controlled release of sirolimus prevented the develo pment of intimal hyperplasia in autologous vein grafts in vivo in rabbits. A perivascularly applied mesh releasing sirolimus is a promising device for preventing stenosis of autologous vein grafts., I. Skalský ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:3

Harvested from:

CDK

Metadata only:

false