The effects of selenium on the antioxidant defense system in the liver of rats exposed to cadmium

Title:

The effects of selenium on the antioxidant defense system in the liver of rats exposed to cadmium

Creator:

Ognjanović, B., Žikić, R. V., Štajn, A., Saičić, Z. S., Kostić, M. M., and Petrović, V. M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9699b100-22f6-4b44-9ec3-48763c9b7893
uuid:9699b100-22f6-4b44-9ec3-48763c9b7893

Subject:

cadmium, selenium, rat, antioxidant defense system, and liver

Type:

article, model:article, and TEXT

Description:

Total superoxide dismutase (total SOD), copper zinc containing superoxide dismutase (CuZn SOD), and manganese superoxide dismutase (Mn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione- S-transferase (GST) activities as well as ascorbic acid (AsA), and vitamin E (vit E) concentrations were analysed in the liver of rats exposed to cadmium (15 mg Cd/day/kg), selenium (7 fig Se/day/kg), and to cadmium + selenium (15 mg Cd + 7 ptg Se/day/kg), and in control animals. Cadmium caused a decrease of total SOD, Mn SOD, CAT and GSH-Px but an increase of GST activity in the liver of rats. Contrary to cadmium, selenium caused a significant increase of the activity of these enzymes except for GSH-Px. By concomitant exposure to both cadmium and selenium, the toxic effects of cadmium on the activity of mentioned enzymes we abolished. In all exposed groups, the activity of enzyme glutathione-S-transferase was enhanced, indicating its increased role in prevention of lipid peroxidation. Cadmium decreased the concentration of AsA and increased the concentration of vitamin E in the liver, while selenium increased the concentration of both vitamins. However, by concomitant administration of cadmium and selenium, these changes were diminished and tended to reach control values.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1995 Volume:44 | Number:5

Harvested from:

CDK

Metadata only:

false