Fructosamine 3-kinase and glyoxalase I polymorphisms and their association with soluble RAGE and abhesion molecules in diabetes

Title:

Fructosamine 3-kinase and glyoxalase I polymorphisms and their association with soluble RAGE and abhesion molecules in diabetes

Creator:

Jan Škrha, Alexandra Muravská, Flekač, M., Horová, E., Novák, J., Novotný, A., Martin Prázný, Kvasnička, J., Landová, L., Marie Jáchymová, Tomáš Zima, and Marta Kalousová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8f0e7cab-a62a-4d79-a41d-7648c07b03ce
uuid:8f0e7cab-a62a-4d79-a41d-7648c07b03ce
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, diabetes mellitus, fructosamine 3-kinase, glyoxalase I, sRAGE, adhesion molecules, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Advanced glycation end-products (AGEs) are key players in pathogenesis of long-term vasc ular diabetes complications. Several enzymes such as fructosamine 3-kinase (FN3K) and glyoxalase I (GLO I) are crucial in preventing glycation processes. The aim of our study was to evaluate an association of FN3K (rs1056534, rs3848403) and GLO1 rs4746 polymorphisms with parameters of endothelial dysfun ction and soluble receptor for AGEs (sRAGE) in 595 diabetic and non-diabetic subjects. Genotypic and allelic frequencies of mentioned polymorphisms did not differ between subgroups. In diabetic patients significant differences were observed in sRAGE concentrations according to their rs1056534 and rs3848403 genotype. While GG and CG genotypes of rs1056534 with mutate d G allele were associated with significant decrease of sRAGE (GG: 1055±458 and CG: 983±363 vs. CC: 1796±987 ng/l, p<0.0001), in rs3848403 polymorphism TT genotype with mutated T allele was related with significant sRAGE increase (TT: 1365±852 vs. CT: 1016±401 and CC: 1087±508 ng/l, p=0.05). Significant differences in adhesion molecules were observed in genotype subgroups of GLO1 rs4746 polymorphism. In conclusion, this is the first study describing significant relationship of FN3K (rs1056534) and (rs3848403) polymorphisms with concentration of sRAGE in patients with diabetes., J. Škrha Jr., A. Muravská, M. Flekač, E. Horová, J. Novák, A. Novotný, M. Prázný, J. Škrha, J. Kvasnička, L. Landová, M. Jáchymová, T. Zima, M. Kalousová., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:Suppl 2

Harvested from:

CDK

Metadata only:

false