Role of oxidative stress and adenosine nucleotides in the liver of aging rats

Title:

Role of oxidative stress and adenosine nucleotides in the liver of aging rats

Creator:

Mármol, F., Sánchez, J., López, D., Martínez, N., Xaus, C., Peralta, C., Roselló-Catafau, J., Mitjavila, M. T., and Puig-Parellada, P.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8790b0bb-ee01-4959-a8f1-ed8d5a2522d1
uuid:8790b0bb-ee01-4959-a8f1-ed8d5a2522d1

Subject:

Fyziologie člověka a srovnávací fyziologie, játra, oxid dusnatý, oxidační stres, liver, nitric oxide, oxidative stress, adenosine nucleotides, rats, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

We studied the response of several parameters related to oxidative stress in the liver of aging rats. Male Wistar rats aged 1.5, 3, 18 and 24 months were used. Livers showed an increase in superoxide anion (O2-) concentration at 1.5 and 18 months of age compared to the 3-month-old group; a decrease in superoxide dismutase (SOD) was seen at 1.5 months and catalase concentrations remained unaltered throughout the aging process. Nitric oxide (NO) progressively declined with age; a significant decrease was particularly apparent at 18 and 24 months of age. Thiobarbituric acid reactive substances (TBARS) decreased significantly at 1.5 months, whereas it increased at 18 and 24 months of age. Concentrations of prostaglandin E2 (PGE2), and adenine nucleotides, and their metabolites, remained unchanged throughout the aging process. Although the mitochondrial damage caused by oxidative stress can result in reduced ATP production and compromised cell function, our results on adenosine nucleotides and their metabolites support the notion that the integrity of mitochondria and enzymatic activity remain mostly unchanged with aging. In conclusion, we observed a significant decrease in the levels of NO in the older groups of rats and hence in its antioxidant activity. This could explain the observed increase in lipid peroxides which suggests an important role for NO in oxidative stress in the liver of older rats., F. Mármol ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:4

Harvested from:

CDK

Metadata only:

false