Gender differences in the effect of prenatal methamphetamine exposure and challenge dose of other drugs on behavior of adult rats

Title:

Gender differences in the effect of prenatal methamphetamine exposure and challenge dose of other drugs on behavior of adult rats

Creator:

Romana Šlamberová, Macúchová, E., Kateryna Nohejlová, Barbora Schutová, Hrubá, L., and Richard Rokyta

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7c0e0b70-93f6-4d81-bf85-6b093d0c9822
uuid:7c0e0b70-93f6-4d81-bf85-6b093d0c9822

Subject:

Fyziologie člověka a srovnávací fyziologie, opioidy, pervitin, opioids, methamphetamine, prenatal methamphetamine, behavior, laboras test, psychostimulants, cannabinoids, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The aim of the present study was to compare the response to acute application of several drugs in adult male and female rats prenatally exposed to metham phetamine (MA). Spontaneous locomotor activity and exploratory behavior of adult male and female rats prenatally exposed to MA (5 mg/kg) or saline were tested in a Laboras apparatus (Metris B.V., Netherlands) for 1 h. Challenge dose of the examined drug [amphetamine - 5 mg/kg; cocaine - 5mg/kg; MDMA (3,4-methylenedioxymethamphetamine) - 5 mg/kg; morphine - 5 mg/kg; THC (delta9-tetrahydrocannabinol) - 2 mg/kg] or saline was injected prior to testing. Our data demonstrate that prenatal MA exposure did not affect behavior in male rats with cocaine or morphine treatment, but increased locomotion and exploration in females. Application of amphetamine and MDMA in adulthood increased activity in both sexes, while cocaine and THC only in female rats. Morphine, on the other hand, decreased the activity in the Laboras test in both sexes. As far as sex and estrous cycle is concerned, the present study shows that males were generally less active than females and also females in proestrus-estrus phase of the estrous cycle were more active than females in diestrus. In conclusion, the present study shows that the pr enatal MA exposure does not induce general sensitization but affects the sensitivity to drugs dependently to mechanism of drug action and with respect to gonadal hormones., R. Šlamberová ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false