In vitro antiproliferative and antiangiogenic effects of Flavin7®

Title:

In vitro antiproliferative and antiangiogenic effects of Flavin7®

Creator:

Ján Mojžiš, Šarišský, M., Martina Pilátová, Viktória Vohárová, Varinská, L., Mojžišová, G., Alexander Ostró, Peter Urdzík, Róbert Dankovčík, and Ladislav Mirossay

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:701fb4cd-98b4-44f5-b8a3-ce5c5bad8127
uuid:701fb4cd-98b4-44f5-b8a3-ce5c5bad8127
issn:0862-8408

Subject:

Experimentální medicína, experimentální medicína, polyfenoly, experimental medicine, polyphenols, antiproliferative, antiangiogenic, Flavin7, 14, and 616-092

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Flavin7 (F7) is a nutritional supplement often taken by cancer patients in Central Europe during chemo- and radiation therapy. In this study, investigation of the antiproliferative and antiangiogenic activities of this supplement were performed. Flavin7 showed antiprolif erative activity in Jurkat as well as in HeLa cells. It significantly reduced the growth of both cancer cell lines at the doses of 200 μg/ml to 20 μg/ml (p<0.001 and p<0.01, respectively). In F7-treated Jurkat cells we found a significant increase in the fraction of cells with sub-G0/G1 DNA content, which is considered to be a marker of apoptotic cell death. Apoptosis was also confirmed by annexin V staining and DNA fragmentation. Furthermore, F7 at the doses of 100 μg/ml to 4 μg/ml inhibited endothelial cell migration and capillary tube formation what indicates its potential antiangiogenic properties. Flavin7 also inhibited the activity of matrix metalloproteinases (MMPs), preferentially MM P-9, at the doses of 100 μg/ml to 4 μg/ml. Our data suggest that F7 possesses marked antiproliferative and antiangiogenic properties in vitro. Further research is needed to elucidate also its in vivo activities., J. Mojžiš, M. Šarišský, M. Pilátová, V. Voharová, L. Varinská, G. Mojžišová, A. Ostro, P. Urdzík, R. Dankovčik, L. Mirossay., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:3

Harvested from:

CDK

Metadata only:

false