Rapid but not slow spinal cord compression elicits neurogenic pulmonary edema in the rat

Title:

Rapid but not slow spinal cord compression elicits neurogenic pulmonary edema in the rat

Creator:

Jiří Šedý, Josef Zicha, Jaroslav Kuneš, Pavla Jendelová, and Eva Syková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:55b182a5-5bd8-45eb-9737-2c0ca3e5dd98
uuid:55b182a5-5bd8-45eb-9737-2c0ca3e5dd98

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, edém, poranění míchy, krevní tlak, pulz (lékařství), krysa obecná, physiology, edema, spinal cord injuries, blood pressure, pulse, Rattus rattus, neurogenic pulmonary edema, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The development of neurogenic pulmonary edema (NPE) can be elicited by an immediate epidural balloon compression of the thoracic spinal cord. To evaluate whether a slower balloon inflation could prevent NPE development, we examined the extent of NPE in animals lesioned with a rapid (5 μl - 5 μl - 5 μl) or slow rate (3 μl - 2 μl - 2 μl - 2 μl - 2 μl - 2 μl - 2 μl) of balloon inflation. These groups were compared with the NPE model (immediate inflation to 15 μl) and with healthy controls. Slow balloon inflation prevented NPE development, whereas the pulmonary index and histology revealed a massive pulmonary edema in the group with a rapid rate of balloon inflation. Pulmonary edema was preceded by a considerable decrease in heart rate during the inflation procedure. Moreover, rapid inflation of balloon in spinal channel to either 5 μl or 10 μl did not cause NPE. Thus, a slow rate of balloon inflation in the thoracic epidural space prevents the development of neurogenic pulmonary edema, most likely due to the better adaptation of the organism to acute circulatory changes (rapid elevation of systemic blood pressure accompanied by profound heart rate reduction) during the longer balloon inflation period. It should be noted that spinal cord transection at the same level did not cause neurogenic pulmonary edema., J. Šedý ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:2

Harvested from:

CDK

Metadata only:

false