Dental composites: a low-dose source of bisphenol A?

Title:

Dental composites: a low-dose source of bisphenol A?

Creator:

Šimková, Markéta, Tichý, Antonín, Dušková, Michaela, and Bradna, Pavel

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:411602d8-5819-464e-81e1-360670e4cc02
uuid:411602d8-5819-464e-81e1-360670e4cc02
issn:0862-8408
doi:10.33549/physiolres.934518

Subject:

bisfenol A, kapalinová chromatografie, hmotnostní spektrometrie, bisphenol A, liquid chromatography, mass spectroscopy, dental composite, release, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Dental composite materials often contain monomers with bisphenol A (BPA) structure in their molecules, e.g. bisphenol-A glycidyl dimethacrylate (Bis-GMA). In this study, it was examined whether dental restorative composites could be a low-dose source of BPA or alternative bisphenols, which are known to have endocrine-disrupting effects. Bis-GMA-containing composites Charisma Classic (CC) and Filtek Ultimate Universal Restorative (FU) and “BPA-free” Charisma Diamond (CD) and Admira Fusion (AF) were examined. Specimens (diameter 6 mm, height 2 mm, n=5) were light-cured from one side for 20 s and stored at 37 °C in methanol which was periodically changed over 130 days to determine the kinetics of BPA release. BPA concentrations were measured using a dansyl chloride derivatization method with liquid chromatography - tandem mass spectrometry detection. The amounts of BPA were expressed in nanograms per gram of composite (ng/g). BPA release from Bis-GMA-containing CC and FU was significantly higher compared to “BPA-free” CD and AF. The highest 1-day release was detected with FU (15.4±0.8 ng/g), followed by CC (9.1±1.1 ng/g), AF (2.1±1.3 ng/g), and CD (1.6±0.8 ng/g), and the release gradually decreased over the examined period. Detected values were several orders of magnitude below the tolerable daily intake (4 µg/kg body weight/day). Alternative bisphenols were not detected. BPA was released even from “BPA-free” composites, although in significantly lower amounts than from Bis-GMA-containing composites. Despite incubation in methanol, detected amounts of BPA were substantially lower than current limits suggesting that dental composites should not pose a health risk if adequately polymerized., Markéta Šimková, Antonín Tichý, Michaela Dušková, Pavel Bradna., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

S295-S304

Source:

Physiological research | 2020 Volume:69 | Number:Supplement 2

Harvested from:

CDK

Metadata only:

false