Inhibition of SRSF3 alleviates proliferation and migration of gastric cancer cells by regulating the PI3K/AKT/mTOR signalling pathway

Title:

Inhibition of SRSF3 alleviates proliferation and migration of gastric cancer cells by regulating the PI3K/AKT/mTOR signalling pathway

Creator:

Xie, J., Sun, Y., and Xu, Qiaoling

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:0bc1527c-8736-4364-b2fc-8a4eb9863b84
uuid:0bc1527c-8736-4364-b2fc-8a4eb9863b84

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

This study was aimed to investigate the impact of serine/arginine-rich splicing factor 3 (SRSF3) on the proliferation and migration of gastric cancer (GC) cells. SRSF3 levels in GC tissues and cell lines were measured by Western blotting. Functional assays were used for evaluation of GC cell proliferation, migration and invasion. The PI3K/AKT/mTOR pathway was then examined by Western blotting. SRSF3 exhibits abnormal expression for the significantly increased levels in GC. SRSF3 knockdown significantly suppressed GC progression. SRSF3 knockdown significantly inhibited activation of PI3K/AKT/mTOR signalling. Inhibition of SRSF3 alleviates proliferation and migration of GC cells, and this process is mediated by inactivation of PI3K/ AKT/mTOR signalling. Targeting SRSF3 may be a promising strategy to combat GC.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

102-107

Source:

Folia biologica | 2021 Volume:67 | Number:3

Harvested from:

CDK

Metadata only:

false