Short-term administration of melatonin or ghrelin on diabetic rats: effects on angiotensin II and vasopressin - induced uterine contractility

Title:

Short-term administration of melatonin or ghrelin on diabetic rats: effects on angiotensin II and vasopressin - induced uterine contractility

Creator:

Georgiev, T., Tolekova, A., Kalfin, R., and Hadzhibozheva, P.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:02a91dec-84a1-4e6f-b3cc-1732fb104285
uuid:02a91dec-84a1-4e6f-b3cc-1732fb104285
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, diabetes mellitus, peptidy, melatonin, peptids, uterine contraction, ghrelin, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aim of the present study was to investigate the effects of Angiotensin II (Ang II) and Arginin-Vasopressin (AVP) on contractility of non-pregnant uterus in diabetic Wistar rats and to explore whether one-week administration of Melatonin (MLT) or Ghrelin (GHR) will change the response of diabetic uterine muscle to AngII and AVP. Uterine horns, prepared by the method of isolated tissues were investigated as w ell as glycemic profile, blood pressure and body weight. The research of smooth muscle contractions was made by a new method of analysis, characterizing in detail the various phases of the myometrial activity. Differences in the development of the peptide-mediated smooth muscle contractions depending on the phase of the estrous cycle were observed. Experimental diabetes had a pronounced negative effect on force and time-parameters of AngII and AVP-stimulated uterine contractions. Administration of GHR or MLT had a beneficial effect on the glycemic status of diabetic rats and partially improved the response of uterine preparations to the peptides. The application of MLT increased both force and time-parameters of Ang II- and AVP-stimulated uterine contractions while treatment with GHR increased power characteristics and shortened contraction and relaxation of the smooth muscle process., T. Georgiev, A. Tolekova, R. Kalfin, P. Hadzhibozheva., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:1

Harvested from:

CDK

Metadata only:

false