Effect of chronic cadmium exposure on antioixdant defense system in some tissues of rats: protective effect of selenium

Title:

Effect of chronic cadmium exposure on antioixdant defense system in some tissues of rats: protective effect of selenium

Creator:

Ognjanović, B. I., Marković, S. D., Pavlović, S. Z., Žikić, R. V., Saičić, Z. S., and Štajn, A. Š.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:010f0c5f-0538-4e75-82f3-1364ecd543ee
uuid:010f0c5f-0538-4e75-82f3-1364ecd543ee
issn:0862-8408

Subject:

Obecná biologie, experimentální biologie, antioxidanty, kadmium, selen, potkan, experimental biology, antioxidants, cadmium, selenium, Rattus norvegicus, antioxidant defense system, 2, and 57

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The effects of selenium (Se) on antioxidant defense system in liver and kidneys of rats with cadmium (Cd)-induced toxicity were examined. Cd exposure (15 mg Cd/kg b.m./day as CdCl2 for 4 weeks) resulted in increased lipid peroxidation (LP) in both organs (p<0.005 and p<0.01). Vitamin C (Vit C) was decreased in the liver (p<0.005), whereas vitamin E (Vit E) was increased in the liver and kidneys (p<0.005 and p<0.05) of Cd-exposed animals. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were decreased in both tissues (p<0.05 and p<0.005), whereas catalase (CAT) activity was decreased only in liver (p<0.005). Glutathione S-transferase (GST) increased in both tissues (p<0.005 and p<0.01). Treatment with Se (0.5 mg Se/kg b.m./day as Na2SeO3 for 4 weeks) significantly increased liver and kidneys SOD and GSH-Px activities (p<0.05 to p<0.005), as well as CAT and GST activities only in the liver (p<0.01). In animals exposed to Se, both the concentrations of Vit C (p<0.01) and Vit E (p<0.005) were increased in both tissues. Co-treatment with Se resulted in reversal of oxidative stress with significant decline in analyzed tissues Cd burden. Our results show that Se may ameliorate Cd-induced oxidative stress by decreasing LP and altering antioxidant defense system in rat liver and kidneys and that Se demonstrates the protective effect from cadmium-induced oxidative damage., B. I. Ognjanović, S. D. Marković, S. Z. Pavlović, R. V. Žikić, A. Š. Štajn, Z. S. Saičić., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:3

Harvested from:

CDK

Metadata only:

false