The significance of ABO blood system groups antigens in development of some malignant tumors is already established. The alteration of hormonal homeostasis must also be taken into account. Hence the aim of the investigation was to study ABO and Rh blood system antigens and hormonal status among reproductive age women with benign and malignant breast tumors. Methods: The determination of hormones was made by the enzymatic analysis method (ELAIZA), provided by proper ELAIZA kits. For the study of ABO and RhHr system antigens, internationally recognized immunoserology methods were used. Results: High index of the breast gland tumors were revealed in patients with A(II) phenotypic group, according to the ABO system. The frequency distribution of O(I) phenotypic group was low among women with breast tumors. Among D, C, E, c and e antigens of the Rh system, the frequency of D and E antigens were increased in benign and malignant breast tumors patients. The study of hormonal balance revealed thyroid gland hypofunction and increased level of estradiol on the background of increased testosterone and decreased progesterone levels. Such hormonal imbalance and excess production of estradiol creates conditions for malignant tumor formation in reproductive age women. Conclusion: The highest frequency of breast cancer in reproductive age was revealed in A(II) group patients. The wide spectrum of hormonal disorders were revealed in breast tumor patients of the reproductive age, which was especially clear in cases of malignant tumor., Irina Nakashidze, Nanuli Kotrikadze, Anzor Diasamidze, Marina Nagervadze, Manana Alibegashvili, Liana Ramishvili, Manana Gordeziani, and Literatura
Červencové číslo Clinical Chemistry (2008) přineslo v sekci Clinical case studies dvě kazuistiky z oblasti tyreoidální laboratorní diagnostiky [1, 2]. První z nich je od jihoafrických autorů (University of Cape Town) a pojednává o nálezu zvýšeného volného tyroxinu u eutyreoidní pacientky. Ve druhé kazuistice čtveřice autorů z Harvardské lékařské fakulty a Dětské nemocnice v Bostonu (Maryland, USA) popisuje zvýšené koncentrace celkového tyroxinu a trijodtyroninu při normálním TSH u mladistvé pacientky se strumou. Oba články doprovodili svými obsáhlými komentáři biochemik Larry J. Kricka (University of Pennsylvania, Philadelphia, USA) a endokrinolog Kenneth D. Burman (Georgetown University, Washington, USA). Kazuistiky i oba komentáře dokládají těsnou souvislost analytické a postanalytické fáze laboratorního cyklu a zásadní význam podrobného kvalifi kovaného pohledu na laboratorní výsledky včetně nutnosti okamžitého řešení zjištěných rozporů. V článku je krátký výtah z těchto článků., Section Clinical Case Studies in July issue of Clinical Chemistry (2008) brought two cases from the sphere of thyroid laboratory diagnostics [1, 2]. The fi rst one by South African authors (University of Cape Town) deals with elevated free thyroxine levels found in an euthyroid woman. Second case described by authors from Harvard Medical School and Children´s Hospital in Boston (MA, USA) discuss discrepancy between normal TSH and higher both total thyroxine and total triiodothyronine found in a girl patient with goiter. Both articles are widely commented by the biochemist Larry J. Kricka (Univ. of Pennsylvania, Philadelphia, PA), and the endocrinologist Kenneth D. Burman (Georgetown Univ., Washington, DC). Clinical cases and commentaries as well performs evidence for the tight connection between analytical and postanalytical phases of laboratory cycle, and a crucial importance of detailed and competent insight into laboratory results including immediate solution of all disagreements discovered. Here we bring a short digest from these articles., Schneiderka Petr, and Lit.: 2