Erythrocyte blood group antigens and alterations of the hormonal status among the reproductive age women with breast tumors

Title:

Erythrocyte blood group antigens and alterations of the hormonal status among the reproductive age women with breast tumors
Erythrocyte blood group antigens and alterations of the hormonal status among the reproductive age women with breast tumors

Creator:

Nakashidze, Irina, Kotrikadze, Nanuli, Diasamidze, Anzor, Nagervadze, Marina, Alibegashvili, Manana, Ramishvili, Liana, and Gordeziani, Manana

Contributor:

Nakashidze, Irina, Kotrikadze, Nanuli, Diasamidze, Anzor, Nagervadze, Marina, Alibegashvili, Manana, Ramishvili, Liana, and Gordeziani, Manana

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc15010744-e0ae4cc2-f5eb-48b1-a526-2e116c3380ea
uuid:bmc15010744-e0ae4cc2-f5eb-48b1-a526-2e116c3380ea
local:bmc15010744
http://ojs.journals.cz/index.php/EMHPJ/issue/archive
isrc: xxx
local: bmc15010744

Subject:

krevní skupiny - systém ABO--imunologie--krev, krevní skupiny - systém Rh-Hr--imunologie--krev, nádory prsu--imunologie--krev--patofyziologie, pohlavní steroidní hormony--krev, tyreoidální hormony--krev, prolaktin--krev, nádorové procesy, dospělí, ženské pohlaví, lidé, lidé středního věku, and kohortové studie

Type:

model:article, article, Text, and TEXT

Format:

electronic, electronic resource, remote, and elektronický zdroj

Description:

The significance of ABO blood system groups antigens in development of some malignant tumors is already established. The alteration of hormonal homeostasis must also be taken into account. Hence the aim of the investigation was to study ABO and Rh blood system antigens and hormonal status among reproductive age women with benign and malignant breast tumors. Methods: The determination of hormones was made by the enzymatic analysis method (ELAIZA), provided by proper ELAIZA kits. For the study of ABO and Rh­Hr system antigens, internationally recognized immunoserology methods were used. Results: High index of the breast gland tumors were revealed in patients with A(II) phenotypic group, according to the ABO system. The frequency distribution of O(I) phenotypic group was low among women with breast tumors. Among D, C, E, c and e antigens of the Rh system, the frequency of D and E antigens were increased in benign and malignant breast tumors patients. The study of hormonal balance revealed thyroid gland hypofunction and increased level of estradiol on the background of increased testosterone and decreased progesterone levels. Such hormonal imbalance and excess production of estradiol creates conditions for malignant tumor formation in reproductive age women. Conclusion: The highest frequency of breast cancer in reproductive age was revealed in A(II) group patients. The wide spectrum of hormonal disorders were revealed in breast tumor patients of the reproductive age, which was especially clear in cases of malignant tumor., Irina Nakashidze, Nanuli Kotrikadze, Anzor Diasamidze, Marina Nagervadze, Manana Alibegashvili, Liana Ramishvili, Manana Gordeziani, and Literatura

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

European medical, health and pharmaceutical journal--MED00177703

Source:

European medical, health and pharmaceutical journal : open access reviewed journal | 2014 Volume:7 | Number:1

Harvested from:

CDK

Metadata only:

false

Date:

2014