The flow of a mixture of liquid and solid particles at medium and high volume fraction through an expansion in a rectangular duct is considered. In order to improve the modelling of the phenomenon with respect to a previous investigation (Messa and Malavasi, 2013), use is made of a two-fluid model specifically derived for dense flows that we developed and implemented in the PHOENICS code via user-defined subroutines. Due to the lack of experimental data, the two-fluid model was validated in the horizontal pipe case, reporting good agreement with measurements from different authors for fully-suspended flows. A 3D system is simulated in order to account for the effect of side walls. A wider range of the parameters characterizing the mixture (particle size, particle density, and delivered solid volume fraction) is considered. A parametric analysis is performed to investigate the role played by the key physical mechanisms on the development of the two-phase flow for different compositions of the mixture. The main focuses are the distribution of the particles in the system and the pressure recovery.