We explored the effect of chronically elevated circulating levels of growth hormone (GH)/insulin -like -growth- factor-1 (IGF-1) on mRNA expression of GH/IGF-1/insulin axis components and p85alpha subunit of phosphoinositide -3-kinase (p85alpha) in subcutaneous adipose tissue (SCAT) of patients with active acromegaly and compared these findings with healthy control subjects in order to find its possible relationships with insulin resistance and body composition changes. Acromegaly group had significantly decreased percenta ge of truncal and whole body fat and increased homeostasis model assessment-insulin resistance (HOMA -IR). In SCAT, patients with acromegaly had significantly increased IGF-1 and IGF -binding protein-3 (IGFBP-3) expression that both positively correlated wit h serum GH. P85alpha expression in SCAT did not differ from control group. IGF-1 and IGFBP-3 expression in SCAT were not independently associated with percentage of truncal and whole body fat or with HOMA -IR while IGFBP -3 expression in SCAT was an independ ent predictor of insulin receptor as well as of p85alpha expression in SCAT. Our data suggest that GH overproduction in acromegaly group increases IGF-1 and IGFBP-3 expression in SCAT while it does not affect SCAT p85alpha expression. Increased IGF-1 or IGFBP-3 in SCAT of acromegaly group do not appear to contribute to systemic differences in insulin sensitivity but may have local regulatory effects in SCAT of patients with acromegaly., V. Touskova, J. Klouckova, V. Durovcova, Z. Lacinova, P. Kavalkova, P. Trachta, M. Kosak, M. Mraz, D. Haluzikova, V. Hana, J. Marek, M. Krsek, M. Haluzik., and Obsahuje bibliografii
Tuková tkáň je endokrinní orgán produkující početné cytokiny. Změna v jejich regulacích může být příčinou patologických pochodů u obézních jedinců. Význam tukové tkáně ve vztahu k diabetu a ateroskleróze je intenzivně studován., Adipose tissue is an endocrine organ that produces numerous cytokines. Their dysregulations cause morbidity in obese individuals. The importance of this tissue in relation to diabetes and atherosclerosis is the subject of intense research., and Ilja Trebichavský, Petr Šíma.
Ještě nedávno se tuková tkáň považovala za pouhou zásobarnu energie a symbol nežádoucí obezity, která má značný podíl na tzv. civilizačních chorobách. Stále víc vědeckých poznatků však začalo podobně jednostranný pohled nabouravat a ukazovat, že tuková tkáň není zbytečné zlo, ale má mnoho důležitých funkcí, bez nichž by se naše tělo neobešlo. and Jana Olivová, Stanislava Kyselová.