Summary characteristics play an important role in the analysis of spatial point processes. We discuss various approaches to estimating summary characteristics from replicated observations of a stationary point process. The estimators are compared with respect to their integrated squared error. Simulations for three basic types of point processes help to indicate the best way of pooling the subwindow estimators. The most appropriate way depends on the particular summary characteristic, edge-correction method and also on the type of point process. The methods are demonstrated on a replicated dataset from forestry.
Studie je replikací experimentu, který přinesl podporu pro hypotézu, že lidé představující si konzumaci jídla sní následně méně jídla než lidé, kteří si konzumaci jídla nepředstavovali. Replikace byla provedena na vzorku 77 vysokoškolských studentů, kteří byli náhodně rozděleni do tří skupin podle různých druhů imaginace. V porovnání s replikovanou studií byl pro analýzy použit větší zkoumaný soubor, byla ověřována úspěšnost manipulace s nezávislou proměnnou a zkoumaným osobám za účast ve výzkumu nebyla nabízena žádná odměna. Na rozdíl od replikované studie nebyl zaznamenán statisticky významný vliv druhu imaginace konzumace jídla na jeho pozdější skutečnou konzumaci. Výsledky nepodporují výsledky původního experimentu a ukazují, že původní výsledky mohly být jen důsledkem náhody. Jsou potřeba další replikace, aby bylo zřejmé, zda je efekt imaginace konzumace na zkonzumované množství jídla skutečný. and This study is a replication of an experiment that has supported a hypothesis that people imagining a consumption of food before its real consumption eat less food than without the prior imagination. The sample consisted of 77 university students who were randomly assigned into three groups varying by amount of imagined objects being consumed. A larger sample has been collected, the level of predictor variable manipulation has been controlled and a no compensation has been offered to the participants in comparison to the replicated study. On the contrary to the primary study, no significant effect of the type of imagined consumption on the consecutive consumption has been found. Results do not support results of the original study and suggest the original study’s outcome might have been achieved at random. More replication is necessary to be able to assess whether the effect of imagination on food consumption is real.
The karyotype of bream Abramis brama was analysed by means of C-banding, replication banding, DAPI fluorescent staining and in situ hybridisation with 18S rDNA and telomeric probes. The use of the in vivo 5-bromodeoxyuridine incorporation technique enabled the induction of replication bands of the RBA type in the karyotype. C-bands corresponded to late replicated chromosome regions. 18S rDNA clusters were found on one chromosome pair. Telomeric sequences were observed only on ends of chromatids. The karyotype morphology and NOR phenotype of A. brama are very similar to those found in other species of the leuciscine cyprinids karyotyped so far.
Since 2007, the year of their first widespread use, genome-wide association studies (GWAS) have become the “gold standard” for the detection of causal genes and polymorphisms in all fields of human medicine. Cardiovascular disease (CVD), one of the major causes of morbidity and mortality, is no except ion. The first GWAS focused on hypercholesterole mia and dyslipid emia as the major CVD determinants. GWAS confirm the importance of most of the previously identified genes (e.g. APOE, APOB, LDL-R) and recogni ze the importance of new genetic determinants (e.g. within the CILP2 or SORT1 gene clusters). Nevertheless, the results of GWAS still require confirmation by independent studies, as interethnic and interpopulation variability of SNP effects have been reported. We analy zed an association between eight variants within seven through GWAs detected loci and plasma lipid values in the Czech post -MONICA population sample (N= 2,559). We confirmed an association (all P<0.01) between plasma LDL-cholesterol values and variants within the CILP2 (rs16996148), SORT1 (rs646776), APOB (rs693), APOE (rs4420638) and LDL-R (rs6511720) genes in both males (N= 1,194) and females (N =1,368). In contrast, variants within the APOB (rs515135), PCSK9 (rs11206510) and HMGCoAR (rs12654264) genes did not significantly affect plasma lipid values in Czech males or females. Unweighted gene score values were linearly associated with LDL-cholesterol values both in males (P<0.0005) and females (P<0.00005). We confirmed the effects of some, but not all analyzed SNPs on LDL-cholesterol levels, reinforcing the necessity for replication studies of GWA-detected gene variants., J. A. Hubacek, V. Adamkova, V. Lanska, D. Dlouha., and Obsahuje bibliografii