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1. Effect of terguride on insulin binding, insulinaemia, glucose tolerance and hyperlipaemia in lean SHR Koletsky rats

Creator:
Golda, V. and Hilgertová, J.
Type:
article, model:article, and TEXT
Subject:
glucose tolerance, insulin binding, insulinaemia, fat pads, plasma cholesterol, plasma triglycerides, and terguride
Language:
English
Description:
Glucose tolerance, insulin binding to erythrocytes, insulinaemia, plasma total cholesterol, plasma triglycerides, weight of fat pads, food consumption and body weight changes were studied in genetically hypertensive lean Koletsky rats. Long-term treatment with dopaminergic agonist terguride (0.2 mg/kg/day) normalized glucose tolerance and increased the percentage of bound insulin to erythrocytes in both sexes. Terguride decreased insulinaemia, cholesterolaemia, fat pads and body weight only in female rats. Food consumption was not influenced by terguride over the injection period.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. High blood pressure of hypertriglyceridaemic rats is related to metabolic disturbances

Creator:
Kuneš, J., Dobešová, Z., and Zicha, J.
Type:
article, model:article, and TEXT
Subject:
hypertension, plasma uric acid, plasma triglycerides, and F2 hybrids
Language:
English
Description:
A set of 131 F2 hybrids, obtained from a cross between normotensive Lewis and hypertensive hypertriglyceridaemic (HTG) rats, was studied in order to assess the relationship between blood pressure, plasma triglycerides and plasma uric acid. In progenitors, the plasma levels of triglycerides and uric acid were twice as high in HTG rats than in the Lewis rats. It was observed In the F2 cohort that high mean arterial pressure (MAP) was unrelated to body weight and relative heart or kidney weights. On the other hand, there were significant correlations between MAP and plasma triglycerides (r=0.420, n=131, p<0.0001) and between MAP and plasma uric acid (r=0.325, p<0.001). Plasma triglycerides of F2 hybrids were below the midparental values, suggesting a stronger influence of normotensive Lewis alleles. In conclusion, hypertension in hypertriglyceridaemic rats strongly cosegregated with plasma triglycerides and plasma uric acid. Our results indicated a linkage between high blood pressure and several metabolic alterations characteristic for the X syndrome.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3. Plasma triglycerides cosegregate with erythrocyte sodium content in F2 rats of HTG x lewis cross

Creator:
Zicha, J., Dobešová, Z., and Kuneš, J.
Type:
article, model:article, and TEXT
Subject:
hereditary hypertriglyceridaemic rats, genetic hypertension, plasma triglycerides, plasma cholesterol, erythrocyte Na+ content, Na+ leak, Na+-K+ cotransport, and Na+-K+ pump
Language:
English
Description:
The possible association of plasma lipids (triglycerides and cholesterol) with erythrocyte Na+ content (Na+j) and/or with alterations in red cell Na+ and K+ (Rb+) transport was studied in a population of F2 hybrids obtained by crossing hypertensive Prague hereditary hypertriglyceridaemic (HTG) rats with normotensive Lewis rats. The obtained data indicated a strong cosegregation (p<0.001) of plasma triglycerides with erythrocyte Na+ content. This was the cause for the close correlation of plasma triglycerides with the Ma+-K+ pump activity (measured as ouabain-sensitive Na+ extrusion). On the contrary, there was only marginal association (p<0.05) of erythrocyte Na+ content with plasma cholesterol which was significantly (p<0.01) related to bumetanide-sensitive Rb+ uptake mediated by the Ma+-K+ cotransport system. Na+ leak (bumetanide-resistant net Na+ uptake) correlated positively with blood pressure in female but not in male F2 rats. The close association between plasma triglycerides and erythrocyte Na+ content suggests that ion transport alterations might contribute to mechanisms responsible for the cosegregation of blood pressure with plasma triglycerides in HTG x Lewis F2 hybrids.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

4. Sex differences in the response of postprandial lipemia to a change from a low-fat low-cholesterol diet to a high-fat high-cholesterol diet

Creator:
Kovář, J. and Rudolf Poledne
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, gender, fyziologie, physiology, postprandial lipemia, plasma triglycerides, 14, and 612
Language:
English
Description:
To determine whether a short-term change in dietary habits affects postprandial lipemia in men and women in the same way, postprandial triglyceridemia was measured in age- and BMI-matched young healthy men and women after two weeks on the self-selected low-fat low-cholesterol (LF) diet and after another two weeks on the self-selected high-fat high-cholesterol (HF) diet. After a standardized challenge meal (1.4 g fat/kg of body weight), men had higher postprandial triglyceridemia than women on the HF diet but no such difference was observed on the LF diet. The results of this preliminary study suggest that there may be important sex differences in the mechanisms regulating the postprandial lipemia response to different diets, women being able to adapt better to the HF diet with respect to postprandial lipemia., J. Kovář, R. Poledne., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public