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Start Over Subject koenzym Q10

1. Treatment with coenzyme Q10, ω-3-polyunsaturated fatty acids and their combination improved bioenergetics and levels of coenzyme Q9 and Q10 in skeletal muscle mitochondria in experimental model of arthritis

Creator:
Kucharská, Jarmila, Poništ, Silvester, Vančová, Oľga, Gvozdjáková, Anna, Uličná, Oľga, Slovák, Lukáš, Taghdisiesfejir, Mohsen, and Bauerová, Katarína
Format:
počítač and online zdroj
Type:
model:article and TEXT
Subject:
artritida, koenzym Q10, arthritis, coenzyme Q10, omega-3-polyunsaturated fatty acids, mitochondrial bioenergetics, skeletal muscle, 14, and 612
Language:
English
Description:
Rheumatoid arthritis (RA) and its animal model adjuvant arthritis (AA) are inflammatory diseases characterized by chronic inflammation, systemic oxidative stress and disturbed mitochondrial bioenergetics of skeletal muscle. The present study aimed to evaluate the effects of coenzyme Q10 - CoQ10 (100 mg/kg b.w.), omega-3-polyunsaturated fatty acids - ω-3-PUFA (400 mg/kg b.w.) and their combined treatment in AA on impaired skeletal muscle mitochondrial bioenergetics, inflammation and changes in levels CoQ9 and CoQ10 in plasma. Markers of inflammation (C-reactive protein, monocytechemotactic protein-1), antioxidant capacity of plasma, respiratory chain parameters of skeletal muscle mitochondria and concentrations of CoQ9 and CoQ10 in plasma and in muscle tissue were estimated. Treatment of the arthritic rats with CoQ10, ω-3-PUFA alone and in combination partially reduced markers of inflammation and increased antioxidant capacity of plasma, significantly increased concentrations of coenzyme Q in mitochondria and improved mitochondrial function in the skeletal muscle. Combined treatment has similar effect on the mitochondrial function as monotherapies; however, it has affected inflammation and antioxidant status more intensively than monotherapies. Long-term supplementary administration of coenzyme Q10 and ω-3-PUFA and especially their combination is able to restore the impaired mitochondrial bioenergetics and antioxidant status in AA., Jarmila Kucharská, Silvester Poništ, Oľga Vančová, Anna Gvozdjáková, Oľga Uličná, Lukáš Slovák, Mohsen Taghdisiesfejir, Katarína Bauerová., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. Vliv volných radikálů na fertilitu muže a možnosti léčby

Creator:
Bittner, Lukáš, Chocholatý, Matúš, Čechová, Marcela, Zima, Tomáš, and Grill, Robert
Format:
print, text, and regular print
Type:
model:article, article, Text, přehledy, and TEXT
Subject:
lidé, mužské pohlaví, mužská infertilita--etiologie--farmakoterapie, oxidační stres--účinky léků, volné radikály--analýza, spermie--fyziologie--účinky léků, varikokéla--komplikace, kyselina askorbová--terapeutické užití, vitamin E--terapeutické užití, selen--terapeutické užití, zinek--terapeutické užití, potravní doplňky, koenzymy--terapeutické užití, antioxidancia--terapeutické užití, alfa-tokoferol--terapeutické užití, and koenzym Q10
Language:
Czech and English
Description:
Příčina neplodnosti infertilního páru v polovině případů stojí na straně muže. Oxidační stres je jedním z důvodů zhoršené plodnosti muže. Článek rozebírá etiologii a mechanizmus vzniku oxidačního stresu a shrnuje současné poznatky o možnostech diagnostiky a léčby oxidačního stresu spermií., In half of the cases of infertility in infertile pairs is due to the pathology of the man. Oxidative stress is one of the reasons of impaired fertility in a male. This article analyses the etiology and mechanism of oxidative stress and summarizes the current state of knowledge regarding the diagnostics options and treatment of oxidative stress of sperm., Lukáš Bittner, Matúš Chocholatý, Marcela Čechová, Tomáš Zima, Robert Grill, and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public