The purpose of this study was to investigate the influence of heat treatment on glucocorticoid (GC) -induced myopathy. Eight -week - old Wistar rats were randomly assigned to the control, Dex, and Dex + Heat groups. Dexamethasone (2 mg/kg) was injected subcutaneously 6 days per week for 2 weeks in the Dex and Dex + Heat group. In the Dex + Heat group, heat treatment was performed by immersing hindlimbs in water at 42 °C for 60 min, once every 3 days for 2 weeks. The extensor digitorum longus muscle was extracted following 2 weeks of experimentation. In the Dex + Heat group, muscle fiber diameter, capillary/muscle fiber ratio, and level of heat shock protein 72 were significantly higher and atrogene expression levels were significantly lower than in the D ex group. Our results suggest that heat treatment inhibits the development of GC -induced myopathy by decreas ing atrogene expression and increasing angiogenesis., Y. Morimoto, Y. Kondo, H. Kataoka, Y. Honda, R. Kozu, J. Sakamoto, J. Nakano, T. Origuchi, T. Yoshimura, M. Okita., and Obsahuje bibliografii
Semi finished glass pieces are moulded in the furnace to template forms not only to fit their shape but also to reduce internal stresses. Thermal differences are unwanted and have to be minimized in the cooling procedure of the glass pieces. Simulations of various types and sizes of shaping forms and complex model cooling were accomplished. The aim of these simulations was to optimise geometric parameters, clamping conditions and material of the form, so that thermal differences at glass are minimized during the cooling. and Článek se zabývá numerickým modelováním změn teplotního pole v materiálu skleněných výlisků v průběhu jejich chlazení po tvarování v elektrické peci. Cílem simulací bylo optimalizovat geometrické vlastnosti, způsob uchycení a materiál formy pro tvarování skleněných výlisků tak, aby teplotní diference ve skle byly co nejmenší.