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31. The mushroom pleurotus ostreatus accelerates plasma very-low-density lipoprotein clearance in hypercholesterolemic rat

Creator:
Bobek, P. and Ozdín, Ľ.
Type:
article, model:article, and TEXT
Subject:
cholesterol, very-low-density lipoproteins, and dietary Pleurotus ostreatus
Language:
English
Description:
The administration of a diet containing 5 % of dried oyster mushroom to male Wistar rats fed a cholesterol diet (0.3 %) shortly after weaning for 8 weeks reduced cholesterol levels in the serum and liver by 27 and 33 %, respectively and increased the fractional turnover rate of 125l-very-low-density lipoproteins (VLDL) by more than 30 %.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

32. The response of hepatic transcriptome to dietary cholesterol in Prague Hereditary Hypercholesterolemic (PHHC) rat

Creator:
Vlachová, M., Marie Heczková, Milan Jirsa, Rudolf Poledne, and Kovář, J.
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, cholesterol, dietní jídla, genetika, genová exprese, hypercholesterolémie, diet, genetics, gene expression, hypercholesterolemia, rat, 14, and 612
Language:
English
Description:
To understand the pathogenesis of hypercholesterolemia in Prague hereditary hypercholesterolemic (PHHC) rat, we analyzed the response of hepatic transcriptome to dietary cholesterol in PHHC and control Wistar rats. Male PHHC and Wistar rats were fed chow (C), 5 % fat (palm kernel oil) (CF) or 1 % cholesterol + 5 % fat (CHOL) diet for three weeks. Hepatic transcriptome was analyzed using Affymetrix GeneChip arrays. No differences were found in the effect of both control diets (C and CF) on lipid metabolism and gene expression of 6500 genes. Therefore, these data were pooled for further analysis. Dietary cholesterol induced accumulation of cholesterol and triacylglycerols in the liver in both strains and hypercholesterolemia in PHHC rats. However, there were no differences in response of hepatic transcriptome to CHOL diet. On the other hand, several genes were found to be differently expressed between both strains independently of the diet. Two of those genes, Apof and Aldh1a7, were studied in more detail, and their role in pathogenesis of hypercholesterolemia in PHHC rats could not been corroborated. In conclusion, the hypercholesterolemia in PHHC rats is due to physiological response of hepatic transcriptome to dietary cholesterol in different genetic background., M. Vlachová, M. Heczková, M. Jirsa, R. Poledne, J. Kovář., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

33. Traditional risk factors of acute coronary syndrome in four different male populations - total cholesterol value does not seem to be relevant risk factor

Creator:
Jaroslav Hubáček, Vladimír Staněk, Gebauerová, M., Věra Adámková, Lesauskaite, V., Zaliaduonyte-Peksiene, D., Tamosiunas, A., Supiyev, A., Kossumov, A., Zhumadilova, A., and Jan Piťha
Format:
print, bez média, and svazek
Type:
article, články, journal articles, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, akutní koronární syndromy, obezita, hypertenze, diabetes mellitus, cholesterol, kouření, acute coronary syndromes, obesity, hypertension, smoking, prevalence, 14, and 612
Language:
English
Description:
Cardiovascular diseases are the most common cause of mortality and morbidity in most populations. As the traditional modifiable risk factors (smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity) were defined decades ago, we decided to analyze recent data in patients who survived acute coronary syndrome (ACS). The Czech part of the study included data from 999 males, and compared them with the post-MONICA study (1,259 males, representing general population). The Lithuanian study included 479 male patients and 456 age-matched controls. The Kazakhstan part included 232 patients and 413 controls. In two countries, the most robust ACS risk factor was smoking (OR 3.85 in the Czech study and 5.76 in the Lithuanian study), followed by diabetes (OR 2.26 and 2.07) and hypertension (moderate risk elevation with OR 1.43 and 1.49). These factors did not influence the ACS risk in Kazakhstan. BMI had no significant effect on ACS and plasma cholesterol was surprisingly significantly lower (P<0.001) in patients than in controls in all countries (4.80 ±1.11 vs. 5.76 ±1.06 mmol /l in Czechs; 5.32 ±1.32 vs. 5.71 ±1.08 mmol /l in Lithuanians; 4.88 ±1.05 vs. 5.38±1.13 mmol /l in Kazakhs/Russians). Results from our study indicate substantial heterogeneity regarding major CVD risk factors in different populations with the exception of plasma total cholesterol which was inversely associated with ACS risk in all involved groups. These data reflect ethnical and geographical differences as well as changing pattern of cardiovascular risk profiles., J. A. Hubacek, V. Stanek, M. Gebauerova, V. Adamkova, V. Lesauskaite, D. Zaliaduonyte-Peksiene, A. Tamosiunas, A. Supiyev, A. Kossumov, A. Zhumadilova, J. Pitha., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public