1. Coenzyme Q10 ameliorates cadmium induced reproductive toxicity in male rats
- Creator:
- Saha, R., Roychoudhury, S., Kumar Kar, K. , Varghese, A. C. , Nandi, P. , Sharma, G. D., Formicki, G., Slama, P., and Kolesarova, A.
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- rat, sperm, oxidative stress, DNA damage, and Cadmium
- Language:
- English
- Description:
- This study aimed at investigating the protective role of CoQ10 against cadmium (Cd)-induced reproductive toxicity in male rats. Adult male Wistar rats were exposed to an acute dose of Cd (25 mg/kg bwt; Cd group), Cd+CoQ10 (25 mg/kg bwt Cd+10 mg CoQ10; Cd-Q10 group) and distilled water (control) in vivo for 15 consecutive days and semen quality was assessed. A significant reduction was noted in sperm concentration, progressive motility, morphology and DNA integrity in both Cdand Cd-Q10 groups in comparison to control indicating Cd-induced testicular lipid per oxidation (LPO) and decline in indigenous antioxidant defense system as measured by total antioxidant capacity (TAC) (p<0.05). However, simultaneous co-administration of CoQ10 along with Cd (Cd-Q10 group) was able to improve sperm concentration, motility, progressive motility, morphology, DNA integrity, and testicular TAC as well as lower LPO compared to Cd group (p<0.05). Results indicate that used dose of CoQ10 is capable of moderately ameliorating reproductive toxicity of Cd by improving semen quality and reducing testicular oxidative stress.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public