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1. Farmakoterapie hluboké žilní trombózy a plicní embolie - 2. část

Format:
braille, text, and regular print
Type:
model:article, article, Text, and TEXT
Subject:
žilní trombóza--terapie, směrnice pro lékařskou praxi jako téma, plicní embolie--terapie, dvojitá slepá metoda, randomizované kontrolované studie jako téma, vitamin K--antagonisté a inhibitory, heparin nízkomolekulární--terapeutické užití, výsledek terapie, beta-alanin--analogy a deriváty, riziko, faktor Xa--antagonisté a inhibitory, antithrombiny--terapeutické užití, antikoagulancia--terapeutické užití, recidiva--prevence a kontrola, Aspirin, hodnocení léčiv, and lidé
Language:
Czech
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

2. The effect of different antioxidants on nitric oxide production in hypertensive rats

Creator:
Kojšová, S., Jendeková, L., Zicha, J., Kuneš, J. , Adriantsitohaina , R., and Pecháňová, O.
Type:
article, model:article, and TEXT
Subject:
N-acetylcysteine, Melatonin, Provinols™, Apocynin, Aspirin, Indapamide, Captopril, and Spirinolactone
Language:
English
Description:
The imbalance between nitric oxide (NO) and reactive oxygen species (ROS) production appears to be a common feature of experimental and human hypertension. Previously, different antioxidants and/or scavengers of oxygen free radicals were shown to activate nitric oxide synthase (NO synthase, NOS) and to increase the expression of both endothelial and neuronal NO synthase isoforms leading to blood pressure reduction. On the other hand, various antihypertensive drugs have been documented to possess antioxidant properties, which may contribute to their beneficial effect on blood pressure. This review is focused on the effects of antioxidant treatment in different models of experimental hypertension with a special attention to the prevention of oxidative damage and the augmentation of NO synthase activity and expression of NOS isoforms.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public