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2. 18-F cholin PET CT v primodiagnostice karcinomu prostaty
- Creator:
- Kudláčková, Šárka, Král, Milan, Koranda, Pavel, and Študent, Vladimír
- Format:
- electronic, electronic resource, and remote
- Type:
- model:article, article, Text, and TEXT
- Language:
- Czech and English
- Description:
- Cíl: Zjistit přínos 18F-fluorocholinového PET/ CT (18F-FCH PET/CT) pro cílenou biopsii prostaty u pacientů s opakovaně negativními biopsiemi a trvajícím podezřením na přítomnost karcinomu prostaty. Soubor pacientů a metoda: Od ledna 2013 do května 2015 jsme provedli 18-F-FCH PET/CT cholinové PET CT vyšetření u 30 pacientů. Indikačním kritériem bylo PSA nad 10 ng/ml a prodělání více než tři biopsií prostaty, včetně biopsie saturační. Pokud to bylo možné, pak pacienti předem prodělali šestitýdenní kůru ATB terapie Doxycyklinem 100mg 2x denně k eliminaci zánětu, a tím možným falešně pozitivním nálezům na 18F-FCH PET/CT. Poté bylo provedeno PET/CT vyšetření a následně s odstupem byla provedena cílená biopsie ložisek popsaných na 18F-FCH PET/CT. Cílená biopsie byla provedena pod sonografickou kontrolou transrektálně za pomoci kognitivní fúze PET/CT obrazu s real-time sonografickým záznamem. Byly odebírány jen vzorky z ložisek popsaných na PET/CT. Výsledky: Od ledna 2013 do května 2015 absolvovalo 18F-FCH PET/CT 30 pacientů. Průměrný věk pacientů byl 66 let v rozmezí 57–75 let. U 14 z nich jsme potvrdili karcinom prostaty, což činí 46% záchyt ve skupině rebiopsií. Všichni tito pacienti měli Gleasonovo skóre vyšší než sedm a PSA vyšší než 20 ng/ml. Závěr: V našem souboru jsme prokázali přínos 18F-FCH PET/CT u pacientů s opakovaně negativními biopsiemi a pokračující elevací PSA, u kterých nebyl karcinom prostaty standardním způsobem detekován. Ložisko vyznačené pomocí 18F-cholinufluorocholinu umožnilo cílenou biopsii pod sonografickou kontrolou. V současnosti není jednoznačné doporučení, jak postupovat u pacientů, u kterých máme opakovaně negativní biopsie prostaty a trvá podezření na přítomnost karcinomu. Využití 18F-FCH PET/CT se jeví jako jedna z mož- ností., Aim: The aim of the study was to determine the benefits of 18F-fluorocholine PET/CT in patients with repeated negative biopsies and continued suspicion of prostate carcinoma. Material and methods: 18F-fluorocholine PET/CT (18F-FCH PET/CT) was performed with 30 patients from January 2013 until May 2015. Indication criteria were PSA above 10 ng/ml and three biopsies. If possible patients underwent six weeks treatment of antibiotic therapy with Doxycyclin 100mg twice per day to eliminate inflammation and possible false findings in PET/CT. Then PET/CT was performed with following targeted biopsy of focus from 18F-FCH PET/CT. Targeted biopsy was done under the sonographic transrectal control with the help of cognitive fusion PET/CT image with real-time sonography. Only samples from centers identified with PET/CT were taken. Results: From January 2013 until May 2015 30 patients underwent 18F-FCH PET/CT. Average age of patients was 66 years (57–75 years). We confirmed prostate cancer in 14 of them which is 46 % success in rebiopsy group. All these patients had Gleason score above seven and PSA higher than 20 ng/ml. Conclusions: We have shown in our sample the benefits of 18F-cholinFCH PET/CT in patients with repeated negative biopsies and continued PSA elevation, where prostate carcinoma was not detected in standard biopsies. The use of 18F-FCH PET/CT seems promising in diagnostic of prostate cancer where 18F-fluorocholine can be found also in slow growing cells of majority of prostate carcinoma. Using this method we can diagnose also tumors, which are located outside of typical areas in the peripheral zone and therefore can be missed even in repeated biopsies., Šárka Kudláčková, Milan Král, Pavel Koranda, Vladimír Študent, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
3. 2nd CCP Phenogenomics Conference 2020: abstract book: Vestec, 17-18 September 2020
- Creator:
- Ústav molekulární genetiky (Akademie věd ČR), České centrum pro fenogenomiku, and CCP Phenogenomics Conference (2020 : Vestec, Praha-západ, Česko)
- Publisher:
- Institute of Molecular Genetics of the Czech Academy of Sciences
- Format:
- electronic, electronic resource, remote, bez média, online zdroj, and 89 stran : ilustrace, převážně barevné, portréty
- Type:
- model:monograph and TEXT
- Subject:
- Obecná genetika. Obecná cytogenetika. Evoluce, fenogenomika, molekulární genetika, phenogenomics, molecular genetics, 575.111:575.21, 577.21, (062.534), (048.3), 2, and 575
- Language:
- English
- Description:
- Název z obálky and born digital
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
4. 3rd CCP Phenogenomics Conference 2021: abstract book: virtual conference: Vestec, 16-17 September 2021
- Creator:
- Ústav molekulární genetiky (Akademie věd ČR), České centrum pro fenogenomiku, and CCP Phenogenomics Conference (2021 : Vestec, Praha-západ, Česko)
- Publisher:
- Institute of Molecular Genetics of the Czech Academy of Sciences
- Format:
- electronic, electronic resource, remote, bez média, online zdroj, and 69 stran : ilustrace, převážně barevné, portréty
- Type:
- model:monograph and TEXT
- Subject:
- Obecná genetika. Obecná cytogenetika. Evoluce, fenogenomika, molekulární genetika, phenogenomics, molecular genetics, 575.111:575.21, 577.21, (062.534), (048.3), 2, and 575
- Language:
- English
- Description:
- Název z obálky and born digital
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
5. 4th CCP Phenogenomics Conference 2022: abstract book: hybrid conference: Vestec, 15-16 September 2022
- Creator:
- Ústav molekulární genetiky (Akademie věd ČR), České centrum pro fenogenomiku, and CCP Phenogenomics Conference (2022 : Vestec, Praha-západ, Česko)
- Publisher:
- Institute of Molecular Genetics of the Czech Academy of Sciences
- Format:
- electronic, electronic resource, remote, bez média, online zdroj, and 82 stran : ilustrace, převážně barevné, portréty
- Type:
- model:monograph and TEXT
- Subject:
- Obecná genetika. Obecná cytogenetika. Evoluce, fenogenomika, molekulární genetika, phenogenomics, molecular genetics, 575.111:575.21, 577.21, (062.534), (048.3), 2, and 575
- Language:
- English
- Description:
- Název z obálky and born digital
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
6. 8th International Symposium on Kallikreins and Kallikrein-Related Peptidases: Prague, 25-27 September 2019 : final programme & abstract book
- Creator:
- Ústav molekulární genetiky (Akademie věd ČR) and International Symposium on Kallikreins and Kallikrein-Related Peptidases 2019 : Praha, Česko)
- Publisher:
- Institute of Molecular Genetics CAS
- Format:
- electronic, electronic resource, remote, bez média, online zdroj, and 78 stran
- Type:
- model:monograph and TEXT
- Subject:
- Biochemie. Molekulární biologie. Biofyzika, molekulární genetika, enzymy, molecular genetics, enzymes, kallikrein, 577.21, 577.15, 612.015.1, 615.355, (048.3), (062.534), 2, and 577
- Language:
- English
- Description:
- Název z obálky, Obsahuje bibliografii a bibliografické odkazy, and born digital
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
7. A comparative study of Ligophorus uruguayense and L. saladensis (Monogenea: Ancyrocephalidae) from Mugil liza (Teleostei: Mugilidae) in southern Brazil
- Creator:
- Marchiori, Natalia C, Pariselle, Antoine, Pereira, Joaber, Agnèse, Jean-François, Durand, Jean-Dominique, and Vanhove, Maarten P.M
- Format:
- electronic, počítač, and online zdroj
- Type:
- model:article and TEXT
- Subject:
- morfologie (biologie), parazitické organismy, morphology (biology), parasitic organisms, molecular systematics, mullet, taxonomy, 2, and 59
- Language:
- English
- Description:
- Representatives of Ligophorus Euzet et Suriano, 1977 were found on the gills of Mugil liza Valenciennes caught in southern Brazil. They were identified as Ligophorus uruguayense Failla Siquier et Ostrowski de Núñez, 2009 and Ligophorus saladensis Marcotegui et Martorelli, 2009, even though specific identification proved to be difficult due to inconsistencies in some diagnostic features reported for these two species. Therefore, a combined morphological and molecular approach was used to critically review the validity of these species, by means of phase contrast and confocal fluorescence microscopical examination of sclerotised hard parts, and assessing the genetic divergence between L. saladensis, L. uruguayense and their congeners using rDNA sequences. The main morphological differences between the two species relate to the shape of the accessory piece of the penis and the median process of the ventral bar. The accessory piece in L. uruguayense is shorter than in L. saladensis, has a cylindrical, convex upper lobe and straight lower lobe (vs with the distal tip of the lower lobe turning away from the upper lobe in the latter species). The ventral bar has a V-shaped anterior median part in L. uruguayense (vs U-shaped in L. saladensis). The two species are suggested to be part of a species complex together with L. mediterraneus Sarabeev, Balbuena et Euzet, 2005. We recommend to generalise such comparative assessment of species of Ligophorus for a reliable picture of the diversity and diversification mechanisms within the genus, and to make full use of its potential as an additional marker for mullet taxonomy and systematics., Natalia C. Marchiori, Antoine Pariselle, Joaber Pereira Jr., Jean-François Agnèse, Jean-Dominique Durand, Maarten P.M. Vanhove., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
8. A comparison of aggression and impulsivity between smokers and non-smokers
- Creator:
- Zaidi, Uzma
- Format:
- electronic, electronic resource, remote, and elektronický zdroj
- Type:
- model:article, article, Text, srovnávací studie, and TEXT
- Subject:
- kouření--epidemiologie--psychologie--škodlivé účinky, agrese--psychologie, impulzivní chování, poruchy vyvolané užíváním tabáku--psychologie, průzkumy a dotazníky, studenti, dospělí, lidé, and mužské pohlaví
- Language:
- English
- Description:
- The study aimed to investigate the role of aggression and impulsivity in smoking among male adult students. It was hypothesized that there would be significant difference between smokers and non- smokers on the traits of aggression and impulsivity. The sample of two hundred male adult students was selected from different universities of Islamabad. Two subscales of Impulsiveness and Aggression were administered to measure the personality traits of aggression and impulsivity. Descriptive statistics and t-test was calculated for analysis of data. Results showed that there is significant differences in aggression and impulsivity between smokers and non-smokers. The result can be helpful for psychologist and other professionals to plan public health therapeutic and social reengineering interventions for youth., Uzma Zaidi, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
9. A cutaneous horn mimicking polydactyly: a case report
- Creator:
- Tamer, Funda and Yuksel, Mehmet Eren
- Format:
- electronic, electronic resource, and remote
- Type:
- model:article, article, Text, and TEXT
- Language:
- English
- Description:
- A cutaneous horn is a general name for cornified material protruding from skin. On the other hand, polydactyly is a common congenital anomaly of the hand and foot which is characterized by extra finger or toe. A cutaneous horn might mimick polydactyly by resembling an extra toe. Hereby, we present a 72-year-old white Caucasian male with an extra toe-like projection on his fourth toe. Initially, polydactyly was suspected, however a cutaneous horn was also considered. The lesion was surgically removed. The histopathological examination of the specimen revealed hyperkeratosis, and thus confirmed the lesion to be a cutaneous horn., Funda Tamer, Mehmet Eren Yuksel, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
10. A giant perineal nevus lipomatosus superficialis: case report
- Creator:
- Tamer, Funda and Yuksel, Mehmet Eren
- Format:
- electronic, electronic resource, and remote
- Type:
- model:article, article, Text, and TEXT
- Language:
- English
- Description:
- Nevus lipomatosus superficialis is a rare hamartomatous malformation which is composed of ectopic adipocytes in the dermis. It was first reported in 1921 by Hoffmann and Zurhelle. Two clinical forms of nevus lipomatosus superficialis have been described: classical (multiple) and solitary. Classical form of nevus lipomatosus superficialis is usually found on pelvic girdle, trunk, buttocks and thighs as soft, skin colored papules or nodules. It is usually present at birth or it appears in the first two decades of life. The solitary form of lipomatosus superficialis appears as a solitary papule or nodule on the back, scalp and arms of the patients with late onset. The lesions are usually asymptomatic, however some patients may complain about pain and itching. Malignant transformation of nevus lipomatosis superficialis has not been reported yet. Therefore, surgical intervention is only necessary for the patients who have cosmetic concerns. Recurrence after surgical removal is very rare. Perineum is an uncommon localization for nevus lipomatosus superficialis. Hereby, we report a 55-year-old Caucasian female with a 6x5,5x4 cm mass in the perineal region. The patient had cosmetic concerns, therefore she wanted the lesion to be removed surgically. The lesion was surgically removed. The histopathological evaluation of the specimen revealed nevus lipomatosus superficialis. A solitary type of giant nevus lipomatosus superficialis in the perineal region of a patient over the age of 50 is a very rare condition. Even rarely seen, nevus lipomatosus superficialis should be kept in mind in the differential diagnosis of perineal masses., Funda Tamer, Mehmet Eren Yuksel, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public